Laparoscopic Hysterectomy Clinical Trial
Official title:
Clearance Rate of Peritoneal Fluid Assessed by Post-operative Ultrasound Decreases After Full Conditioning Pneumoperitoneum
Measurement of residual peritoneal fluid after laparoscopic surgery
Primary endpoints
- to evaluate whether the clearance rate of peritoneal fluid is exponential or linear
over time. (absorption rate expected for Adept ~30-60 ml/h)
- to evaluate the role of the mesothelial barrier in this clearance rate.
Knowing that diffusion to and from peritoneal fluid decreases with increasing molecular
weight (MW), our hypothesis is that clearance rate will decrease following peritoneal
conditioning. Indeed a decreased mesothelial trauma (either through hypoxia or through
denudation) and retraction will expose less the basal membrane
Secondary endpoints:
-To confirm the decrease in post-operative pain as measured by VAS-score and inflammation as
measured by CRP and leucocytosis with the full conditioning of the pneumoperitoneum.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention
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