Laparoscopic Cholecystectomy Clinical Trial
Official title:
Kidney Function After Laparoscopic Cholecystectomy and Tramadol Anesthesia Plus Dipyrone or Ketorolac
double blind study of kidney function of two groups of adult patients submitted to laparoscopic cholecystectomy and analgesia from tramadol associated to dipyrone or ketorolac
Background: The laparoscopic cholecystectomy (LC) reduces surgical trauma and hospital stay
but requires effective and safe postoperative analgesia. This prospective and double blind
study aimed to study the effects of tramadol analgesia associated to dipyrone or ketorolac
in the kidney function of patients submitted to LC, using creatinine (Cr), cystatin C, and
enzymuria evaluations.
Methods: In the pre- and postoperative (PO) periods, estimated glomerular filtration rates
(GFR), obtained from two formulas dependants of blood Cr and one from blood cystatin C
values, and tubular enzymuria - alkaline phosphatase (AP), γ-glutamyltransferase (γ-GT) -
were determined in patients who underwent LC and analgesia with tramadol and dipyrone (G1,
n=63) or tramadol and ketorolac (G2, n=63). In the recovery room (RR), pain and need of
rescue analgesia with morphine were evaluated.
;
Observational Model: Case-Only, Time Perspective: Prospective
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