Language Delay Clinical Trial
Official title:
Identification of Hereditary Auditory Temporal Processing Deficits
Verified date | September 18, 2018 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Some children with certain language disorders may not properly process the sounds they hear,
resulting in language impairments. The purpose of this study is to determine if deficits in
auditory temporal processing the way the brain analyzes the timing and patterns of sounds are
an inherited trait.
Families with auditory temporal processing deficits are sought in order to identify the genes
responsible for auditory temporal processing deficits. Children and adults with a diagnosis
or history of language impairment in the family and their family members both affected and
non-affected are eligible for this two-part study. In Part 1, participants undergo a series
of language tests and listening tests to measure various characteristics of how they perceive
sound. In Part 2, they are interviewed about language disorders, learning disabilities, and
other medical problems of family members. This information is used to construct a pedigree
(family tree diagram) showing the pattern of inheritance of family traits. Study subjects
whose pedigree indicates that language disorders may be hereditary in their family will
provide either a small blood sample (1 to 2 tablespoons) or a tissue specimen obtained from a
cheek swab (rubbing the inside of the cheek with a small brush or cotton swabs). The sample
will be used to isolate DNA for genetic analysis.
Status | Terminated |
Enrollment | 875 |
Est. completion date | September 18, 2018 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | All |
Age group | 6 Years to 85 Years |
Eligibility |
- INCLUSION CRITERIA: 6-85 years of age Native English speaker, with English as the first language Phase 1 Same sex twins (MZ or DZ) and both willing and able to participate in test procedures. Phase 2 Score in the top or bottom 10th percentile on tests of auditory processing or are a first-degree relative of someone who scores in the top or bottom 10th percentile and are willing and able to participate in the test procedures. EXCLUSION CRITERIA: Hearing loss, defined as air conduction pure tone thresholds (250-8000 Hz) exceeding 20 dBHL; air-bone gaps, even in the presence of normal hearing sensitivity, exceeding 10 dBHL; and/or abnormal tympanometry. History of chronic (fluid in middle ear for more than 4 months) or recurrent otitis media (more than 4 episodes of acute otitis media in one year) History of ear surgery. History or diagnosis of a central nervous system disorder, including but not limited to: - Intracranial tumors - Cerebrovascular disease - Degenerative CNS disorder - CNS trauma - Encephalitis - Meningitis - Auditory neuropathy - Attention deficit hyperactivity disorder (ADHD) - Attention deficit disorder (ADD) Currently taking medications capable of altering CNS function (e.g. antidepressants, anxiolytics, or a psychostimulant drugs such as ritalin). History of treatment with ototoxic medications that may affect ultrahigh frequency hearing (e.g. cisplatin, aminoglycoside antibiotics). Unable to provide consent or assent |
Country | Name | City | State |
---|---|---|---|
United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute on Deafness and Other Communication Disorders (NIDCD) |
United States,
Bishop DV. Autism, Asperger's syndrome and semantic-pragmatic disorder: where are the boundaries? Br J Disord Commun. 1989 Aug;24(2):107-21. Review. — View Citation
Bishop DV. Is specific language impairment a valid diagnostic category? Genetic and psycholinguistic evidence. Philos Trans R Soc Lond B Biol Sci. 1994 Oct 29;346(1315):105-11. Review. — View Citation
Tomblin JB, Records NL, Buckwalter P, Zhang X, Smith E, O'Brien M. Prevalence of specific language impairment in kindergarten children. J Speech Lang Hear Res. 1997 Dec;40(6):1245-60. — View Citation
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