Movement Disorders Clinical Trial
Official title:
Blood Lactate Levels in Patients Treated With Typical or Atypical Antipsychotics
Blood lactate levels in patients receiving typical or atypical antipsychotics have not been
described in the literature.
The goal of this study is to assess the dynamics of lactate levels in the blood from typical
or atypical antipsychotics not confounded by prior antipsychotic treatments, the
investigators conducted a prospective study of lactate levels in patients receiving
antipsychotic medication. The investigators hypothesized that 6 months of treatment with
haloperidol or olanzapine would result in a change in blood lactate levels and
extrapyramidal side effects.
The aim of this study was to compare the blood lactate levels in patients receiving typical
or atypical antipsychotics.
Subjects included sixty patients with psychotic disorder were assigned to treatment for 6
months with haloperidol (typical antipsychotic), N=30 or olanzapine (atypical
antipsychotic), N=30. Blood lactate levels, other metabolic parameters, and scores on the
extrapyramidal symptom rating scale (ESRS) were assessed.
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Observational Model: Cohort, Time Perspective: Prospective
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