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Lactic Acidosis clinical trials

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NCT ID: NCT03723993 Withdrawn - Lactic Acidosis Clinical Trials

Remote Ischemic Preconditioning During Cardiopulmonary Bypass

RIPC
Start date: January 15, 2018
Phase: N/A
Study type: Interventional

The objective of study is to detect effect of remote ischemic preconditioning on serum lactate levels during and after cardiac surgery with cardiopulmonary bypass in addition to its effect on cardiac and renal clinical outcomes.

NCT ID: NCT03122678 Withdrawn - Septic Shock Clinical Trials

Thiamine Supplementation in Patients With Septic Shock

Start date: November 5, 2016
Phase: Phase 1
Study type: Interventional

To determine if intravenous thiamine would decrease the time to reversal of shock in patients with septic shock.

NCT ID: NCT01973504 Withdrawn - Trauma Clinical Trials

Phase 2c Dose Comparison Study of MP4OX in Trauma

Start date: December 2013
Phase: Phase 2
Study type: Interventional

MP4OX is being developed as an ischemic rescue therapy to perfuse and oxygenate tissues at risk during hemorrhagic shock. MP4OX is a pegylated hemoglobin-based colloid designed to improve perfusion and target delivery of oxygen to ischemic tissues. This study will evaluate safety and efficacy of MP4OX treatment, in addition to standard therapy, in trauma patients suffering from lactic acidosis due to severe hemorrhagic shock.

NCT ID: NCT00638040 Withdrawn - Hypoxia Clinical Trials

The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression

Start date: September 2009
Phase: N/A
Study type: Observational

The purpose of this study is to analyze the gene expression patterns associated with various microenvironmental stresses in tumors to understand their roles in tumor progression and treatment responses. To achieve this goal, we will perform gene expression analysis of the tumor samples collected from an IRB-approved study (IRB #: 4516-05-2R2) International Phase III Study of Chemoradiotherapy versus Chemoradiotherapy Plus Hyperthermia for Locally Advanced Cervical Cancer directed by Dr. Mark Dewhirst. We will correlate the gene expression signatures of different microenvironmental stresses with the measured physiological parameters to understand their role in tumor progression, treatment response and clinical outcomes.