Clinical Trials Logo

Clinical Trial Summary

This purpose of this study is to investigate whether lactation improves insulin sensitivity and increases lipolysis in women.


Clinical Trial Description

There are two aims that this research will address. In Aim 1, the research question is "Does lactation improve insulin sensitivity and increase lipolysis in women?" In this Aim, researchers will assess whether lactation amongst women with a history of gestational diabetes mellitus (GDM) will improve whole body insulin sensitivity as well as increase whole body lipid turnover by using hyperinsulinemic-euglycemic clamps combined with [6,6-2H]-glucose and [2H5]-glycerol infusions. These stable, non-radiating isotopes have been used extensively and safely to study the mechanisms of insulin resistance amongst non-pregnant as well as pregnant humans; however, these techniques have not previously been applied to the study of insulin sensitivity during lactation. Therefore, the goals will be two-fold: 1) to determine whether lactation induces similar changes in insulin sensitivity in humans as in mice and 2) to pilot the feasibility of performing larger, more detailed metabolic studies in this population of women post-partum. The second aim (Aim 2) will use a retrospective chart review of women with a history of GDM who had an oral glucose tolerance test (OGTT) 6-8 weeks post-partum as part of standard of care. The focus of this protocol registration will be Aim 1. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04146909
Study type Interventional
Source Yale University
Contact
Status Terminated
Phase N/A
Start date November 17, 2020
Completion date November 28, 2022

See also
  Status Clinical Trial Phase
Completed NCT02542527 - Evaluation of the Functionality of a Fluid Filled Single Breast Pump N/A
Terminated NCT02755194 - "Drugs in Lactation" Analysis Consortium
Terminated NCT00851591 - Effect of Fenugreek on Milk Production N/A
Withdrawn NCT00181649 - Recombinant Human Prolactin for Lactation Induction Phase 2
Completed NCT00181610 - Recombinant Human Prolactin for Lactation Induction Phase 2
Completed NCT04024865 - Domperidone and Risk of Serious Cardiac Events in Postpartum Women
Terminated NCT02378233 - Iodine Status in Swedish Lactating Women - Effect of Iodine Supplementation in the Thyroid Function of Mother and Infant N/A
Recruiting NCT06203444 - An Open-label Study to Evaluate the Pharmacokinetics of Oral Tenapanor in Breast Milk of Lactating Females Phase 1
Completed NCT01747668 - Lactation Fortification Study Phase 3
Completed NCT01463202 - Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression Phase 4
Completed NCT02621827 - Vitamin D Half-life in Pregnancy and Lactation N/A
Completed NCT04593719 - Effect of Lactation Management Model on Breastfeeding Process N/A
Completed NCT01548313 - The Role of Human Milk in Development of Breast Fed Child's Intestinal Microbiota
Completed NCT02690675 - Iron Supplement Effect on Child Development N/A
Completed NCT05123183 - Nonpharmacological Methods and Lactation N/A
Completed NCT03091985 - Influence of the Brownie Breast Shield on the Dynamics of Milk Removal N/A
Completed NCT02190448 - Randomized, Placebo-Controlled Study of an Herbal Tea to Support Lactation N/A
Not yet recruiting NCT06264349 - Women and Maternity: Development of a Nutritional Education Project N/A
Recruiting NCT02384655 - Effect of Fenugreek Use in Mothers of Preterm on Breast Milk Production and Macronutrient Content Phase 1/Phase 2
Completed NCT02662517 - Growth Hormones and Cells in Human Milk Depending on Gestational Age