Labor Trial Refused Clinical Trial
Official title:
The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis: a Randomized Clinical Trial
This study aims to evaluate the effect of dentifrice formulations containing Centella asiatica and bamboo salt on gingivitis and dental plaque. Participants uses dentifrice which contains Centella asiatica and bamboo salt and the same participants will also use placebo for tooth brushing by cross-over design.
With growing interest in plant-based products among researchers, many toothpastes with
various herbal extracts have been introduced over the past few decades,Centella asiatica
(CA), a small herb broadly cultivated in China, Southeast Asia, India and Oceanic countries,
has long been used for therapeutic purposes since ancient times.CA has been reported to be
useful in the treatment of skin diseases wound repair and healing of burn. In dentistry, few
studies have explored the efficacy of CA. In one study, CA was demonstrated to be an
effective supportive agent following periodontal treatment, resulting in reduced plaque and
gingivitis. In spite of such wound healing properties of CA, its usage in dental field has
been limited.
Bamboo salt (BS) is a Korean folk remedy consisting of sea salt roasted in bamboo which has
long been used for therapeutic purposes in Korea. Toothpastes containing BS has been sold in
Korea for some decades. Some in vitro studies and animal studies using rats demonstrated
anti-inflammatory effects of BS. Nevertheless, no human study has yet evaluated the effect
of BS on periodontal health.
Therefore, the new dentifrice containing CA and BS was developed.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention