Correlation Between Coital Activity During Pregnancy & NCT00433303

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number	NCT00433303
Other study ID #	Intercourse-Prostanoid DP
Secondary ID
Status	Not yet recruiting
Phase	N/A
First received	February 8, 2007
Last updated	February 8, 2007

Study information
Verified date	February 2007
Source	Shaare Zedek Medical Center
Contact	Michael Schimmel, Prof.
Phone	972-2-6550689
Email	schimmel[@]New.szmc.org.il
Is FDA regulated	No
Health authority	Israel: Ministry of Health
Study type	Observational

Clinical Trial Summary

The purpose of our study is correlate between premature delivery (between week 23-35 of the pregnancy) in women that had intercourse up to 12 hours prior to beginning of labor and polymorphisms in the gene Prostanoid receptor.

Description:

During the past years there has been a conflict between different studies regarding the correlation between intercourse during pregnancy and early labor. Brustman et al showed that women that were at a high risk for early delivery and had intercourse and then an early labor had significantly increase uterine activity compared to women at low risk. Petridou et al showed that this risk is significantly higher at week 33 of gestation. However, the Cochrane Library summary leaves the question of correlation between intercourse and early labor unanswered. In Sayle et al's study showed no correlation between early delivery and intercourse. In 2004 Oguma described 3 polymorphisms in the Prostanoid receptor gene. These polymorphisms were correlated to increased activity of smooth muscles of bronchi in asthma. Since this gene is also expressed in the uterine muscles we wanted to determine whether there is a correlation between the three polymorphisms T-549C, C-441T, T-197C, G+1044A and early delivery due to intercourse.

1. Brustman LS, Raptoulis M. Langer O, Anyaegbunam A & Merkatz IR. Changes in the pattern of uterine contractility in relationship to coitus during pregnancies at low and high risk for preterm labor. Obstet Gynecol 1989;73:166-168

2. Petridou E, Salvnos H, Skalkidou A, Dessypris N, Moustaki M & Trichopoulos D. Are there common triggers of preterm deliveries. British J Obst Gynecol 2001;108:598-604)

3. Kavanagh J, Kelly AJ & Thomas J. Sexual intercourse for cervical ripening and induction of labour. The Cochrane Database of Systematic Reviews 2001, Issuse 2.Art. No.:CD003093. DOI: 10.1002/14651858.CD003093

4. Sayle AE, Savitz DA, Thorp JM, Hertz-Picciotto I & Wilcox AJ. Sexual activity during late pregnancy and risk of preterm delivery. Obstet Gynecol 2001;97:283-9)

5. Bernal AL. Mechanisms of labour-biochemical aspects. BJOG 2003;110(Supp 20):39-45

6. Oguma T, Palmer L, Birden E, Sonna LA, Asano K& Lilly CM. Role of prostanoid dp receptor variants in susceptibility to asthma. NEJM 2004;351:1752-63

Recruitment information / eligibility
Status	Not yet recruiting
Enrollment	0
Est. completion date
Est. primary completion date
Accepts healthy volunteers
Gender	Female
Age group	20 Years to 40 Years
Eligibility	Inclusion Criteria: - Women who start delivery in weeks 23-35 of pregnancy 12 hours after intercourese. - Women who come for delivery after week 31 and have not had intercourse during the previous month. - Women at term who have been sexually active during their pregnancy. Exclusion Criteria: - Any other women who come in for delivery.

Study Design

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal

Related Conditions & MeSH terms

Intervention

Behavioral:
• Correlation between early delivery and coital activity

Locations
Country	Name	City	State
Israel	Shaare Zedek Medical Center	Jerusalem

Sponsors *(1)*
Lead Sponsor	Collaborator
Shaare Zedek Medical Center

Country where clinical trial is conducted

Israel,

References & Publications (1)

Brustman LE, Raptoulis M, Langer O, Anyaegbunam A, Merkatz IR. Changes in the pattern of uterine contractility in relationship to coitus during pregnancies at low and high risk for preterm labor. Obstet Gynecol. 1989 Feb;73(2):166-8. — View Citation

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04437576` - Pregnancy and Latent Labor Biomarkers and Symptoms to Predict Cervical Dilation at Hospital Admission.
Completed	`NCT05527236` - The Effects of Breathing Exercises and Virtual Reality Applications During Pregnancy and Labor.	N/A
Not yet recruiting	`NCT02493192` - Birth Ball Versus Meperidine and Haloperidol Injection for Pain Relief During First Stage of Labour	Phase 4
Terminated	`NCT02021539` - The Prognostic Value of Cervical Elastography for Identifying Patients at Risk for Preterm Delivery	N/A
Completed	`NCT05109247` - Prediction of Spontaneous Onset of Labor at Term

Correlation Between Coital Activity During Pregnancy and Premature Delivery Related to Prostanoid Receptor Polymorphisms

Clinical Trial Details — Status: Not yet recruiting

Administrative data

Study information