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The Role of Oxytocin in the Second Stage of Labor — ROSSoL  

Labor Complication Clinical Trial

Official title:
Role of Oxytocin in the Second Stage of Labor: a Randomized Controlled Trial (The ROSSoL Trial)

Clinical Trial Summary

This is a randomized controlled trial investigating the utility of oxytocin administration in the second stage of labor.

Clinical Trial Description

Oxytocin is widely used on Labor and Delivery units throughout the world.Laboring patients are most likely to initiate oxytocin in the first stage of labor. Among those who receive oxytocin, first stage initiation is far more common than second stage initiation. The goal of first stage administration is to increase uterine contractility and cause cervical dilation, particularly in patients who have epidural analgesia. Once complete cervical dilation has been achieved, most providers choose to continue oxytocin in the second stage of labor for the theoretic benefit of increased expulsion "power" while pushing. This practice is currently not evidence-based as the limited data thus far suggests no difference in operative deliveries with the use of oxytocin augmentation in general. The benefits and risk of oxytocin continuation in the second stage of labor is unknown. Oxytocin administration is associated with the risk of uterine tachysystole, postpartum hemorrhage,and maternal hyponatremia. These risks call for a closer look at prolonged oxytocin use past the first stage of labor. This is a randomized controlled trial investigating the utility of oxytocin administration in the second stage of labor. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04303702
Study type Interventional
Source Washington University School of Medicine
Contact Nandini Raghuraman, MD MSCI
Phone 9186917389
Email nraghuraman@wustl.edu
Status Recruiting
Phase N/A
Start date July 1, 2022
Completion date June 30, 2025
View Details
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