The Effect of a Prolonged Peripheral Nerve Block on the Level of Pain After a Knee Replacement

Knee Replacement Surgery Clinical Trial

Official title:

The Effect of a Prolonged Peripheral Nerve Block (Utilazing Continuous Adductor Canal Block on the Level of Pain After a Knee Replacement Surgery

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06382285
• Other study ID #: 0206-22-ASF
• Status: Not yet recruiting
• Phase: N/A
• Start date: October 30, 2024
• Est. completion date: January 31, 2026

Study information

• Verified date: April 2024
• Source: Assaf-Harofeh Medical Center
• Contact: Sara Bar Yehuda, PhD
• Phone: 972528981004
• Email: sarabar1[@]shamir.gov.il
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to examine the effect of a prolonged peripheral nerve block (utilizing continuous adductor canal block) on the level of pain after a knee replacement surgery

Description:

Knee replacement surgery is one of the common orthopedic surgeries for the treatment of chronic knee pain. The period after knee replacement surgery is accompanied by moderate to severe pain that affects the patient's ability to quickly return to function. Peripheral nerve blockers and analgesia of different types, administered as part of the anesthesia process, are optimal in controlling pain after surgery. After the surgery, the patients are admitted in the orthopedic inpatient department for 2-3 days on average after surgery for follow-up and early physical therapy necessary to achieve good results and return the patient to full function as soon as possible. The level of pain greatly affects the success rate of the patient's rehabilitation. Thus, since the duration of peripheral nerve block activity does not exceed 8-16 hours on average, it is suggested to treat the patients with a prolonged peripheral nerve block (utilizing continuous adductor canal block) for 24 hours after surgery.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: January 31, 2026
• Est. primary completion date: October 30, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Female and male patients between the ages of 18 and 80 who have signed an informed consent form.
• ASA is less than 3
• Spinal anesthesia

Exclusion Criteria:

• Patients with sensitivity to the anesthetic.

Related Conditions & MeSH terms

• Knee Replacement Surgery

Intervention

Drug:
• Continues peripheral block
ropivacaine (Naropin) 0.2% according to a protocol 8-10 cc per hour up to 24 hours after surgery

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assaf-Harofeh Medical Center

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pain level	Documentation of pain level during the hospitalization days every 12 hours (on a scale of 1-10)	during hospitalization (1-2 days)
Primary	Analgesic use	Documentation of pain level during the hospitalization days every 12 hours (on a scale of 1-10).; Documentation of analgesic administration in hospitalization.	during hospitalization (1-2 days)
Secondary	Physiotherapy	Documentation of the execution of a full or partial physical therapy program	during hospitalization (1-2 days)