Knee Pain Chronic Clinical Trial
Official title:
Efficacy of Platelet-rich Plasma Injections for the Treatment of Persistent Medial Knee Pain After Total Knee Arthroplasty
This study will investigate the potential effects of platelet rich plasma for the treatment of persistent medial knee pain after total knee arthroplasty. All study participants will receive PRP injections and will be followed up to see if any benefit in regards to pain and/or function is achieved.
This study aims to investigate the efficacy of platelet-rich plasma (PRP) injections for the
treatment of persistent medial knee pain after total knee arthroplasty (TKA). The
investigators hypothesize that PRP injections will provide meaningful pain relief and
improved functionality for patients suffering from post-TKA residual pain. The incidence of
residual pain after TKA ranges between 10-34%. Many of these patients can be effectively
managed by physical therapy, orthotics, and pes anserine bursa corticosteroid injections.
However, there remain a number of refractory cases that are frustrating for both the patient
and physician. With the advent of interventional pain management, advanced interventions for
this clinical problem have focused on selective nerve blocks and ablations targeting the
infrapatellar branch of the saphenous nerve. More recently, attention has been paid to the
role of patient biology and inflammatory mediators in the development of post-arthroplasty
pain (including IL-6 and CRP). If individual patient biology is the foundation of post-TKA
pain, then biologic interventions aimed at restoring the balance of these mediators (such as
PRP), rather than ablative procedures, seems preferable. Furthermore, while intra-operative
PRP has been studied for its effects on wound healing, blood loss, and post-operative pain
control, no study has investigated its utility in treating residual medial knee pain after
TKA.
All injections will be performed by the same board-certified sports medicine and
musculoskeletal ultrasound physician. There will be no activity restrictions following the
procedure.
Descriptive statistics will be used to report mean changes in outcome scores. Data will be
analyzed with a 2-sample t-test.
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