| Eligibility |
Inclusion Criteria:
1. Obtain informed consent prior to the commencement of any activities related to the
trial, have a full understanding of the purpose and significance of the trial, and be
willing to comply with the trial protocol;
2. Age 18 ~ 55 years old (including boundary value), male or female;
3. Male weight = 50 kg, female weight = 45 kg, body mass index (BMI) = weight (kg) /
height 2 (m2), BMI in the range of 19 ~ 28 kg/m2 (including boundary value);
4. Random pre-physical examination, vital signs, laboratory tests (blood routine, urine
routine, blood biochemistry, coagulation function), thyroid function, chest
radiograph, 12-lead ECG results are normal or abnormal and have no clinical
significance;
5. Subjects and their partners who have no fertility plan and voluntarily take highly
effective contraception during the study period to the last follow-up of the trial
(the last follow-up time between dose groups is shown in Table 9), 6 months (female
subjects receiving SHR-2106) or 3 months (male subjects receiving SHR-2106) and
voluntarily take highly effective contraception (see Annex 1 of the protocol for
specific contraceptive measures), female subjects must have a negative serum pregnancy
test and be non-lactating.
Exclusion Criteria:
1. The subject's medical history, symptoms and examination results at the time of
screening suggest active tuberculosis or latent tuberculosis. All participants will be
screened for TB status by ? interferon gamma release assay (IGRA) and chest radiograph
(x-ray). Participants who underwent IGRA and x-ray examination within 1 month prior to
screening may, at the discretion of the investigator, not repeat IGRA and x-ray at
screening;
2. History of severe cardiovascular, liver, kidney, digestive tract, psychiatric,
hematology, metabolic and other diseases (within 5 years);
3. Those who have serious infection, severe trauma or major surgery within 6 months
before screening or administration; those who plan to undergo surgery during the
trial;
4. Those who have chronic infection or recurrent infection within 12 months before
screening and need treatment;
5. Those who donated blood or lost a total of =200 mL within 1 month before screening or
administration, or = 400 mL of blood donation or blood loss within 3 months before
administration, or who received blood transfusion within 2 months;
6. Those who have a history of allergies to two or more foods and drugs; or a known
history of allergy to the study drug or any component of the study drug (see Annex 2
of the protocol for injectable ingredients);
7. History of tobacco addiction within 3 months before screening, defined as: an average
of more than 5 cigarettes smoked per day; or those who are unable to comply with the
no-smoking requirements during the study;
8. Alcoholics within 3 months before screening (1 day intake of alcohol more than 15 g
for women, more than 25 g for men [5 g of alcohol is equivalent to 150 mL of beer, 50
mL of wine or about 17 mL of low-alcohol liquor], more than 2 times a week) or
positive alcohol breath test at baseline;
9. Systolic blood pressure (SBP) before screening or administration: SBP = 140 mmHg or <
90 mmHg; diastolic blood pressure (DBP) :D BP= 90 mmHg or < 50 mmHg;
10. Glutaminase (AST) or alanine aminotransferase (ALT) at screening= 2 times the upper
limit of normal range (ULN), or total bilirubin = 1.5 times ULN
11. Those with abnormal coagulation function and clinically significant, or those who have
bleeding tendency or are receiving thrombolysis or anticoagulation therapy, or those
who need to receive preventive anticoagulation therapy during the test
12. Those at risk of thromboembolic events (such as history of thromboembolism,
cardiovascular disease, diabetes, recurrent spontaneous miscarriage, dyslipidemia);
13. Abnormal and clinically significant 12-lead ECG results before screening or
administration (e.g., male QTcF> 450 ms; QTcF for women >470 ms);
14. Those who are positive for urine drug screening during the screening period; or those
with a history of substance abuse within the previous 2 years of screening;
15. Those who are positive for infectious disease screening (including hepatitis B virus
surface antigen, hepatitis C virus antibody, human immunodeficiency virus antibody,
syphilis antibody) during the screening period;
16. Those who received live (attenuated) vaccine within 4 weeks before screening or
planned to be vaccinated during the trial;
17. Those who plan to take any prescription drug, over-the-counter drug or Chinese herbal
medicine that is not the test drug of the study during the screening period or 1 month
before administration or within 5 half-lives of the drug (whichever is longer), or
plan to take any nutritional supplement during the trial period that is not the test
drug of the study (except for occasional use of acetaminophen in the recommended dose
(the total amount of medication for one day does not exceed 2 g and the continuous
dose does not exceed three days)) or plan to take any nutritional supplement during
the trial period;
18. Those who have participated in other clinical trials or within the 5 half-lives of the
investigational drug within 3 months before screening (subject to the intervention of
the investigational drug or medical device, whichever is longer);
19. Have received any of the following therapies at any time: a) B-cell targeted therapy
(e.g., rituximab, other anti-CD20 drugs, anti-CD22 [epratuzumab], anti-CD52
[alemtuzumab], BLyS receptor fusion protein [BR3], TACI-Fc); b) Abatacept;
20. Any physical or mental illness or condition that, as determined by the study
physician, may increase the risk of the trial, affect the subject's adherence to the
protocol, or affect the subject's completion of the trial.
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