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Validation of Gene Expression Markers of Renal Allograft Functional Decline

Kidney Transplant Recipients Clinical Trial

Official title:
Multicenter Validation of Gene Expression Markers of Renal Allograft Functional Decline (GEN-04)

Clinical Trial Summary

The purpose of this study is to determine if certain genes found in a kidney biopsy performed at one-year post transplant can predict which transplanted kidneys will have decreased kidney function within five years post-transplant.

Clinical Trial Description

Gene expression profiling is used to study the activity of genes. Each gene has an "on/off" switch that controls how they are expressed in a cell, as well as a "volume control" that increases or decreases the level of expression of a particular gene as necessary. Researchers want to see if the presence and abundance of certain transcripts in a kidney biopsy at one year after transplant can predict which kidneys will have reduced function over time. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01782586
Study type Observational
Source National Institute of Allergy and Infectious Diseases (NIAID)
Contact
Status Completed
Phase
Start date March 2013
Completion date March 2018
View Details
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