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NCT00204178 Clinical Trial

The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney

Kidney Transplantation Clinical Trial

Official title:
The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT00204178
Other study ID # KB/38/2003
Secondary ID
Status Active, not recruiting
Phase N/A
First received September 13, 2005
Last updated November 30, 2005
Start date April 2003
Est. completion date September 2005

Study information
Verified date August 2005
Source Uniwersytet Mikolaja Kopernika w Toruniu
Contact n/a
Is FDA regulated No
Health authority Poland: Ministry of Health
Study type Observational

Clinical Trial Summary

Measurement of reactive oxygen species production and antioxidant system status before and directly after reperfusion of the transplanted kidney and influence of oxidant stress on kidney function in 2 and 6 weeks.

Description:

Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ. In kidney transplant recipients following factors were measured: glutathione level, activities of glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan.

Blood was sampled from peripheral vein (before reperfusion) and directly from renal vein (5 and 15 minutes after reperfusion).

Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 60
Est. completion date September 2005
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- consecutive patients accepted for and undergoing cadaveric kidney transplantation

Exclusion Criteria:

- no informed consent

Study Design

Observational Model: Defined Population, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Intervention

Behavioral:
• Oxidative stress in kidney transplant recipients

Locations
Country Name City State
Poland Klinika Transplantologii, Szpital Uniwersytecki, ul. M. Sklodowskiej-Curie 9 Bydgoszcz

Sponsors (1)
Lead Sponsor Collaborator
Uniwersytet Mikolaja Kopernika w Toruniu

Country where clinical trial is conducted

Poland, 

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