Kidney Scarring Post-Febrile UTI Clinical Trial
| NCT number | NCT00868270 |
| Other study ID # | HY55-08 |
| Secondary ID | |
| Status | Not yet recruiting |
| Phase | N/A |
| First received | March 22, 2009 |
| Last updated | March 22, 2009 |
| Start date | May 2009 |
The prevalence of kidney scarring after UTI is approximately 5-57%. UTIs are caused mainly by bacteria that cause local and systemic immunological reaction that are accompanied by cytokines. These cytokines are a main factor in the inflammatory process. They are produced by leukocytes, macrophages, fibroblasts, endothelial cells and epithelial cells in the kidney tissue. Interleukin 6 and 8 (IL-6 IL-8) were found in high levels in the urine of children and adults who suffer from UTIs. Other studies on animals have found a relationship between inflammatory reaction and scarring in the kidney. We hypothesize that we will find a similar relationship between the level of IL-6, IL-8 in the urine during acute pyelonephritis in children and the probability of kidney scarring.
| Status | Not yet recruiting |
| Enrollment | 35 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | N/A to 7 Years |
| Eligibility |
Inclusion Criteria: - Children aged 0-7 - First episode febrile UTI Exclusion Criteria: - Recurrent UTI |
Observational Model: Cohort, Time Perspective: Prospective
| Country | Name | City | State |
|---|---|---|---|
| Israel | Hillel Yaffe Medical Center | Hadera |
| Lead Sponsor | Collaborator |
|---|---|
| Hillel Yaffe Medical Center |
Israel,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | High prevalence of kidney scarring in children with high levels of urine interleukins | six months | No |