GLP-1: Acute Effects on Kidney Function in Healthy Men

Kidney Functional Clinical Trial

Official title:

GLP-1: Acute Effects on Kidney Function in Healthy Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01333163
• Other study ID #: VEKRM 29414
• Status: Completed
• Phase: N/A
• First received: April 8, 2011
• Last updated: December 14, 2011
• Start date: May 2011
• Est. completion date: December 2011

Study information

• Verified date: December 2011
• Source: University of Aarhus
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: The Regional Committee on Biomedical Research EthicsDenmark: Danish Dataprotection Agency
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate how Glucagon-Like Peptide 1 (GLP-1) affects kidney function in healthy young men. The hypothesis is that GLP-1 induces a positive effect on kidney hemodynamics.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: December 2011
• Est. primary completion date: December 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Healthy young men

Exclusion Criteria:

• Any chronic diseases

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Kidney Functional

Intervention

Biological:
• Human GLP-1 (7-36) amide
2 hour IV infusion, 1,5pmol/min/kg.
• Isotone NaCl
2 hours IV infusion.

Locations

Country	Name	City	State
Denmark	Klinisk Institut, Afd. MEA, Aarhus Sygehus, NBG	Aarhus C

Sponsors (2)

Lead Sponsor	Collaborator
Jeppe Skov	Novo Nordisk A/S

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Glomerular Filtration Rate		Every 20 minutes for 6 hours	No