Kidney Failure, Chronic Clinical Trial
Official title:
The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease
Indoxyl sulfate (IS) is a uremic toxin that accelerates the progression of chronic kidney
disease (CKD). AST-120 (Kremezin®; Kureha Corporation, Tokyo, Japan) removes indole, which
is the precursor of IS, in the intestine, and reduces the accumulation of IS. This drug has
been shown to retard the deterioration of renal function in CKD patients through reducing
the levels of IS.
IS was reported to promote aortic calcification and stimulate the proliferation of vascular
smooth muscle cells (VSMC). IS also inhibits endothelial proliferation and wound repair.
With this background, the investigators will performed the study whether AST-120 improve the
endothelial dysfunction in CKD patients.
The purpose of this study is to examine whether Kremezin, Indoxyl sulfate lowering agent improve endothelial dysfunction in stage 3,4 chronic kidney disease patients ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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