AKIN Criteria: Acute Kidney Injury After On-Pump Coronary Artery Bypass Graft (CABG)

Kidney Failure Clinical Trial

Official title:

AKIN (Acute Kidney Injury Network): Acute Kidney Injury After On-Pump Coronary Artery Bypass Graft Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00780845
• Other study ID #: CAAE-3438.0.000.140-08
• Status: Completed
• Phase: N/A
• First received: October 27, 2008
• Last updated: November 3, 2008
• Start date: January 2003
• Est. completion date: January 2008

Study information

• Verified date: October 2008
• Source: Hospital de Base
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Observational

Clinical Trial Summary

The purpose of this study is evaluate clinical outcomes and 30-day mortality after on-pump CABG.

Description:

Eight hundred and seventeen patients was enrolled in this series and divided into to groups: Group AKI (-) - patients without acute kidney injury after on-pump CABG. Group AKI (+) - patients with acute kidney injury after on-pump CABG. AKI was defined as an absolute increase in serum creatinine (SCr) of more than or equal to 0.3 mg/dl (≥ 26.4 μmol/l) or a percentage increase in SCr of more than or equal to 50% (1.5-fold from baseline). The change in SCr concentration was defined as the difference between immediate postoperative concentration and the highest concentration during the stay in ICU. Clinical Outcomes and 30-day mortality was evaluate in this patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 817
• Est. completion date: January 2008
• Est. primary completion date: January 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients underwent on-pump coronary artery bypass grafting

• Patients with at least two serum creatinine values within 48 hours.

Exclusion Criteria:

• Patients with end-stage kidney disease requiring renal replacement therapy.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Acute Kidney Injury
• Kidney Failure
• Renal Insufficiency

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Hospital de Base

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To test the hypothesis that patients with acute kidney injury after on-pump CABG have higher 30-day mortality		30 days	No
Secondary	To compare clinical outcomes in patients with and without acute kidney injury after on-pump CABG		30 days	No