Kidney Disease Clinical Trial
Official title:
Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients
NCT number | NCT00485706 |
Other study ID # | ML4181 |
Secondary ID | S50455 |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | June 2007 |
Verified date | October 2018 |
Source | Universitaire Ziekenhuizen Leuven |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Renal patients have an increased risk for cardiovascular complications. There is also
increased vascular calcification and bone metabolism is similarly abnormal in patients with
chronic kidney disease.
In dialysis patients frequent episodes of hypercalcaemia occur. In a healthy bone structure
those episodes of hypercalcemia are buffered by the bone. The absence of bone buffering
capacity in dialysis patients can be a mechanism for vascular calcifications.
Status | Completed |
Enrollment | 0 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: - maintenance hemodialysis patients Exclusion Criteria: - dialysis <3 months - aortobifemoral graft - calcium level predialysis >10.5 mg/dl |
Country | Name | City | State |
---|---|---|---|
Belgium | UZ Gasthuisberg | LEuven |
Lead Sponsor | Collaborator |
---|---|
Universitaire Ziekenhuizen Leuven |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | correlation between calcium increase and pulse wave velocity | correlation between calcium increase and pulse wave velocity | ||
Primary | correlation between calcium change and pth change | correlation between calcium change and pth change | ||
Secondary | correlation between calcium increase and vascular calcifications | correlation between calcium increase and vascular calcifications | ||
Secondary | correlation between calcium change and bone markers | correlation between calcium change and bone markers |
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