Retrospective Study: Long-term Health of Living Kidney Donors

Kidney Diseases Clinical Trial

Official title:

Long-term Medical and Psychological Implications of Becoming a Living Kidney Donor: A Historical Matched Cohort Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00319527
• Other study ID #: R-04-078
• Secondary ID: LKD Retrospectiv
• Status: Completed
• Start date: May 2004
• Est. completion date: March 2008

Study information

• Verified date: February 2024
• Source: Lawson Health Research Institute
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Kidney transplantation, is the preferred treatment option of end stage renal disease. Compared to dialysis, patients who receive kidneys have a 70% reduction in death, a dramatically improved quality of life and cost the health care system considerably less. As a result, there are over 3000 Canadians on the waiting list for a kidney. In order to meet the shortage of cadaveric kidneys, the rates of living kidney donation have nearly doubled over the last 10 years. Yet despite its advantages for the recipient, living kidney donation remains a complex ethical, moral, and medical issue. The premise for accepting living donors is that the "minimal" risk of short and long-term medical harm realized by the donor is outweighed by the definite advantages to the recipient and potential psychosocial benefits of the altruistic gift to the donor. The only benefit for the living donor is psychological - donors experience increased self-esteem, feelings of well-being, and improved health related quality of life with their altruistic act of assuming medical risk to help another. The short-term consequences of living donation are well established. On the other hand the long-term consequences of living kidney donation are far less certain. The main medical concerns of living kidney donation include an increased risk of hypertension, proteinuria, and low glomerular filtration rate (GFR- a measure of the filtering capacity of the kidney). Estimates of these outcomes are variable, inconsistent, and uncertain in the literature. This study is designed to quantify the long-term medical and psychosocial implications of living kidney donation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 311
• Est. completion date: March 2008
• Est. primary completion date: March 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age greater than 18 years old

• Living kidney transplant occurred between 1970 and 2006

• no history of hypertension, kidney disease or proteinuria prior to donation

Exclusion Criteria:

• a medical condition (such as cardiovascular disease, pulmonary disease, or active cancer) which makes one ineligible to be a donor. Blood group and immunological incompatibility (such as positive cross-match, poor HLA matches) are not reasons for exclusion.

• The eligible non-donor subsequently went on to donate a kidney

• Either the donor or the eligible non-donor are unable to give informed consent

• The living donor or eligible non-donor is currently pregnant

Related Conditions & MeSH terms

• Kidney Diseases

Locations

Country	Name	City	State
Australia	Sir Charles Gairdner Hospital	Nedlands	Western Australia
Canada	University of Alberta	Edmonton	Alberta
Canada	Dalhousie University	Halifax	Nova Scotia
Canada	St. Joseph's Hospital	Hamilton	Ontario
Canada	London Health Sciences Centre	London	Ontario
Canada	The Ottawa Hospital	Ottawa	Ontario
Canada	St Michaels Hospital	Toronto	Ontario
Canada	University Health Network	Toronto	Ontario
Canada	St. Paul's Hospital	Vancouver	British Columbia
United Kingdom	Western Infirmary	Glasgow

Sponsors (2)

Lead Sponsor	Collaborator
Lawson Health Research Institute	National Kidney Foundation

Countries where clinical trial is conducted

Australia,  Canada,  United Kingdom,