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NCT00018785 Clinical Trial

Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants

Kidney Disease Clinical Trial

Official title:
Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00018785
Other study ID # IMMU-035-98S
Secondary ID
Status Completed
Phase N/A
First received July 3, 2001
Last updated January 20, 2009
Start date October 1998
Est. completion date September 2003

Study information
Verified date December 2004
Source VA Office of Research and Development
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Interventional

Clinical Trial Summary

Diabetes and end-stage kidney, liver and heart disease are prominent health issues among veteran patients. Successful solid organ transplantation in the absence of chronic immunosuppressive therapy (specific acquired immunological tolerance) is a desirable therapeutic option. This project extends recent observations supporting the use of concommitant donor bone marrow cell infusion as a means of modulating the immune response in kidney transplantation, thereby allowing a substantial decrease or withdrawal of potentially toxic immunosuppressive drugs.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date September 2003
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group N/A and older
Eligibility Living related donor kidney transplant recipients and the living related donors.

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Intervention

Procedure:
• donor bone marrow infusion

Locations
Country Name City State
United States VAMC Miami Miami Florida

Sponsors (1)
Lead Sponsor Collaborator
VA Office of Research and Development

Country where clinical trial is conducted

United States, 

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