Kidney Damage Clinical Trial
Official title:
To Evaluate the Renal Tubular Function Pre and Post Nephrectomy in Living Donors
The overall goals of this study are to demonstrate the change in renal tubular function in living donors pre and post nephrectomy at 6 months.
The physiologic sequelae of living kidney donation are still poorly understood.
Uni-nephrectomy from donation results in decreased number of glomeruli and research has shown
that there is glomerular hyperfiltration and glomerular hypertrophy. Uni-nephrectomy also
results in a decreased number of tubules, but there is not much data about possible tubular
injury post donation and its long term effects on donors.
Our overall hypothesis is that post uni-nephrectomy tubular function, measured by maximum
urine concentration capacity, will be decreased and may be a more sensitive marker of kidney
damage than standard tests, such as urine albumin, serum creatinine, estimated glomerular
filtration rate (eGFR), or measured urine creatinine clearance (CrCl). The goal of this study
is to evaluate the effect of uni-nephrectomy on renal tubular function and its potential in
being an early and more sensitive marker in kidney injury when compared to standard tests.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT01781819 -
(ARFI) Shear Velocity Imaging of the Kidneys in Pediatric Patients
|
N/A |