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NCT01544569 Clinical Trial

Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors

Kidney Cancer Clinical Trial

Official title:
Endogenous DNA Transposition in Rhabdoid Tumors

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01544569
Other study ID # AREN12B3
Secondary ID COG-AREN12B3CDR0
Status Completed
Phase N/A
First received February 29, 2012
Last updated May 17, 2016
Start date March 2012

Study information
Verified date May 2016
Source Children's Oncology Group
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer.

PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.

Description:

OBJECTIVES:

- To investigate the expression and function of transposons in 50 primary rhabdoid tumors.

OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.

Recruitment information / eligibility
Status Completed
Enrollment 50
Est. completion date
Est. primary completion date May 2016
Accepts healthy volunteers No
Gender Both
Age group N/A to 1 Year
Eligibility DISEASE CHARACTERISTICS:

- Freshly frozen rhabdoid tumors from either renal or extra-renal sites from children younger than 2 years of age

- Clinical patient information (age, gender, comorbidities, tumor stage, size, pathology, therapy, outcome) available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective

Related Conditions & MeSH terms

Intervention

Genetic:
• DNA analysis

• fluorescence in situ hybridization

• gene expression analysis

• gene mapping

• microarray analysis

• polymerase chain reaction

• protein expression analysis

Other:
• laboratory biomarker analysis

• medical chart review

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
Children's Oncology Group National Cancer Institute (NCI)

Outcome
Type Measure Description Time frame Safety issue
Primary Expression and function of transposons in rhabdoid tumors No
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