Kidney Cancer Clinical Trial
Official title:
Pilot Case-Control Study of WT1 Mutations in Wilms Tumor Patients Who Develop ESRD
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory
may help doctors learn more about changes that occur in DNA and identify biomarkers related
to cancer.
PURPOSE: This research study is studying biomarkers in blood and tumor tissue samples from
patients with Wilms tumor.
OBJECTIVES:
- To determine whether Wilms Tumor (WT) patients without WT1-associated congenital
anomalies or syndromes, but with end-stage renal disease (ESRD) unrelated to
progressive bilateral tumors, carry germline WT1 mutations.
- To determine whether non-syndromic WT1 germline mutation carriers have a substantially
higher incidence of ESRD than do WT patients who do not harbor WT1 mutations.
OUTLINE: Archived blood and tumor tissue specimens (or DNA isolated from these samples) are
analyzed for WT1 mutations by gene sequencing and PCR.
;
Observational Model: Case Control, Time Perspective: Retrospective
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