Kidney Cancer Clinical Trial
Official title:
Assessment of Patterns of Expression of VEGF, Matrix Metalloproteinase 2, 9 Activity, E-Cadherin Regulation and CA-9 Activity as Predictors of Aggressive Renal Cell Carcinoma Behavior
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is looking at tumor tissue samples from patients who have
undergone surgery for localized kidney cancer.
OBJECTIVES:
- To identify consistent patterns of VEGF expression, E-cadherin regulation, matrix
metalloproteinase 2 and 9 activity, and carbonic anhydrase 9 activity as predictive
factors in the development of aggressive tumor behavior in tumor tissue samples from
patients with localized clear cell renal cell carcinoma.
OUTLINE: Previously collected tumor tissue samples are examined by immunohistochemistry for
levels of expression of five different factors related to aggressive tumor behavior (i.e.,
VEGF expression, E-cadherin regulation, matrix metalloproteinase 2 and 9 activity, and
carbonic anhydrase 9 activity). Samples are compared to positive tissue controls (i.e.,
VEGF- tonsil; E- cadherin-normal breast or endometrium; MMP2- placenta) and a negative
control (i.e., isotype matched normal serum) to identify consistent patterns of
expression/activity of these factors. Levels of expression are quantified as 5-level scores
(0 to 4 scale) and differences between any two areas of a tumor are analyzed.
;
Observational Model: Case Control, Time Perspective: Prospective
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