Kidney Cancer Clinical Trial
Official title:
PET/CT Evaluation of Subjects Treated on Surgery Branch Adoptive Cell Therapy Protocols
RATIONALE: Diagnostic procedures, such as positron emission tomography and computed
tomography scan (done before and after cellular adoptive immunotherapy), may help doctors
predict a patient's response to treatment and help plan the best treatment.
PURPOSE: This phase II trial is studying how well positron emission tomography and computed
tomography scan predicts response in patients with metastatic melanoma or kidney cancer who
are undergoing cellular adoptive immunotherapy on a Surgery Branch clinical trial.
OBJECTIVES:
Primary
- Measure changes in metabolic activity at visceral sites during the acute treatment
phase of adoptive cell transfer (ACT) using positron emission tomography (PET)/CT
fusion imaging in patients with metastatic melanoma or renal cell cancer.
- Measure changes in metabolic activity at metastatic sites during the acute treatment
phase of ACT using PET/CT fusion imaging.
- Compare the changes in metabolic activity at visceral and metastatic sites in patients
treated with intravenous vs intra-arterial tumor-infiltrating lymphocyte infusions.
Secondary
- Correlate response of individual metastases with these metabolic alterations.
OUTLINE: This is a pilot study. Patients are stratified according to treatment (intravenous
[IV] tumor-infiltrating lymphocytes [TIL] after a nonmyeloablative preparative regimen vs
intra-arterial [IA] TIL after a nonmyeloablative preparative regimen vs IV TIL after a
myeloablative preparative regimen with chemotherapy and total-body irradiation).
Patients undergo positron emission tomography with fludeoxyglucose F 18 (FDG-PET)/CT fusion
imaging at baseline (before starting TIL infusion), once between days 1-4 after TIL
infusion, and once between days 5-8 after TIL infusion.
PROJECTED ACCRUAL: A total of 70 patients will be accrued for this study.
;
Primary Purpose: Diagnostic
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