Kidney Cancer Clinical Trial
Official title:
Adoptive Immunotherapy by Allogeneic Stem Cell Transplantation for Metastatic Renal Cell Carcinoma: A Phase II Study
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Peripheral stem cell transplantation may be able to replace
immune cells that were destroyed by chemotherapy used to kill tumor cells.
PURPOSE: Phase II trial to study the effectiveness of chemotherapy followed by donor
peripheral stem cell transplantation in treating patients who have metastatic or
unresectable kidney cancer.
OBJECTIVES:
- Determine the overall response rate and overall and disease-free survival of patients
with unresectable or metastatic renal cell cancer treated with fludarabine and
cyclophosphamide followed by allogeneic peripheral blood stem cell transplantation.
- Determine the toxicity and treatment-related mortality of this regimen in these
patients.
- Determine the percentage of donor chimerism in patients treated with this regimen.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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