Kidney Cancer Clinical Trial
Official title:
A Phase II, Open-Label, Multicenter Trial of Angiozyme in Subjects With Metastatic Renal Cell Cancer
RATIONALE: RPI.4610 may stop the growth of metastatic kidney cancer by stopping blood flow
to the tumor.
PURPOSE: Phase II trial to study the effectiveness of RPI.4610 in treating patients who have
metastatic kidney cancer.
OBJECTIVES: I. Determine the response rate of patients with metastatic renal cell cancer
treated with RPI.4610. II. Determine the percentage of these patients with stable disease at
16 weeks after starting treatment with this drug. III. Assess the safety and tolerability of
this drug in these patients.
OUTLINE: This is a multicenter study. Patients receive RPI.4610 subcutaneously daily.
Treatment continues for 16 weeks in the absence of disease progression or unacceptable
toxicity. Patients with stable or responding disease may continue treatment after 16 weeks.
Patients are followed every 3 months.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
;
Primary Purpose: Treatment
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