Kidney Cancer Clinical Trial
Official title:
TREATMENT OF METASTATIC RENAL CELL CARCINOMA WITH SUBCUTANEOUS RECOMBINANT INTERLEUKIN-2 AND INTERFERON ALPHA
RATIONALE: Biological therapies use different ways to stimulate the immune system to try to
stop cancer cells from growing. Combining interferon alfa and interleukin-2 may kill more
tumor cells.
PURPOSE: Phase II trial to study the effectiveness of interferon alfa and interleukin-2 in
treating patients with metastatic kidney cancer.
OBJECTIVES:
- Evaluate the response and disease-free survival of patients with metastatic renal cell
carcinoma treated with subcutaneous interleukin-2 and interferon alfa.
- Assess the toxicity of this regimen.
OUTLINE: Patients undergo nephrectomy if the diseased kidney makes up the bulk of the tumor
burden.
All patients receive subcutaneous interferon alfa on day 1 and interleukin-2 on days 3-5 of
week 1, followed by reduced doses of interferon alfa and interleukin-2 on days 1, 3, and 5
of weeks 2-6. Patients are assessed for response approximately 2 months after initiating
therapy. Patients with stable or responding disease undergo a second course; those who
continue to respond may receive additional therapy provided toxicity is limited.
Patients are followed for survival.
PROJECTED ACCRUAL: 14 patients will be entered.
;
Primary Purpose: Treatment
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