Clinical Trials Logo

Clinical Trial Summary

Ketones are natural substances normally produced by the body during prolonged fasting and starvation, or in response to a "ketogenic" diet to be used as fuel by the brain and muscles. Ketones are therefore similar to dietary proteins, carbohydrates and fats since they represent a source of energy for the body. In addition to serving as a source of energy, ketones have also been shown to stimulate increased rates of muscle protein synthesis in humans. The ingestion of dietary protein is well established to stimulate an increase in the rate of protein synthesis in skeletal muscle. The rate of muscle protein synthesis can be maximized following the intake of 20g of protein. As a result, smaller doses of protein (i.e. 10g) represent a sub-optimal dose of protein because there is still room for improvement concerning muscle protein synthesis. Recently ketone-containing food products have become available that elevate ketone levels in the body without the need for ketogenic diets or prolonged fasting. Therefore, the purpose of this study is to measure skeletal muscle protein synthesis rates after ingesting the following: 1. Ketone monoester 2. Ketone monoester supplemented with sub-optimal dose of whey protein 3. Sub-optimal dose of whey protein It is hypothesized that muscle protein synthesis rates will increase following the ingestion of a ketone-containing beverage. Further, muscle protein synthesis rates will be enhanced when the ketone-containing beverage and sub-optimal protein dose are taken together.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Ketosis
  • Regulation of Muscle Protein Synthesis

NCT number NCT04565444
Study type Interventional
Source McGill University
Contact
Status Completed
Phase N/A
Start date September 21, 2020
Completion date May 14, 2021

See also
  Status Clinical Trial Phase
Completed NCT04477161 - Effect of Ketone Esters in Parkinson's Disease N/A
Active, not recruiting NCT05477368 - Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults With Type 2 Diabetes N/A
Completed NCT04817176 - MI-CBT Adherence Program for Lifestyle Interventions in Older Adults Early Phase 1
Not yet recruiting NCT06418074 - Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity N/A
Not yet recruiting NCT03954665 - Ketone Supplementation and Exercise Performance N/A
Active, not recruiting NCT06097754 - Intermittent Exogenous Ketosis (IEK) at High Altitude N/A
Terminated NCT03790436 - Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet N/A
Completed NCT03299543 - Comparison Between Breath Acetone and Blood Beta-Hydroxybutyrate
Recruiting NCT04004676 - Ketone Supplementation, Glycogen Replenishment and Time Trial Performance Following Glycogen Lowering Exercise N/A
Not yet recruiting NCT03659825 - Ketone Esters for Optimization of Cognitive Performance in Hypoxia N/A
Active, not recruiting NCT04156477 - Markers of Appetite Regulation During Exogenous Ketosis N/A
Completed NCT04130724 - Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status
Recruiting NCT04594265 - Weight-Adjusted Dosing of 3-OHB in Patients With Chronic Heart Failure Phase 2
Not yet recruiting NCT04576026 - Exogenous Ketone Supplementation and Cognitive Function During Exercise N/A
Completed NCT05558488 - The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response N/A
Recruiting NCT03564002 - Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity
Completed NCT04309214 - Market Research - Acceptability Study for New MCT Fat Products N/A
Completed NCT05588427 - Effect of Ketone Ester Supplementation on Hypoxic Tolerance N/A
Recruiting NCT05656339 - Metabolic Effects of Whey Protein Supplementation After Fasting in Volunteers N/A
Active, not recruiting NCT04737694 - Ketone Supplements and Substrate Oxidation and Physical Performance N/A