Double Pet Project : A Comparison Between 11C-Acetate and 11C-acetoacetate Heart and Kidney Uptake

Ketoses, Metabolic Clinical Trial

Official title:

Double Pet Project : A Comparison Between 11C-Acetate and 11C-acetoacetate Heart and

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05238805
• Other study ID #: 2022-4540
• Status: Completed
• Phase: N/A
• Start date: March 14, 2022
• Est. completion date: August 14, 2022

Study information

• Verified date: January 2023
• Source: Université de Sherbrooke
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The objective of this study is to make a comparison between 11C-acetate and 11C-Acetoacetate heart and kidney metabolism

Description:

Healthy people will have two positron emission tomography scan to perform. One, with a 11C-Acetate Tracer and the other with 11C-Acetoacetate. The results will allow to determine if both tracers are used in a similar way but the organs and see if the investigators can use the already validated analyse method for acetate to make acetoacetate analysis

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: August 14, 2022
• Est. primary completion date: August 14, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• Aged between 18 and 55

• BMI between 18,5 and 28

• Healthy

• Normal value for blood pressure

Exclusion Criteria:

• Taking drugs that could influence metabolism

• Diabetes or prediabetes

• Pregnancy or lactation

• Participation in a intensive sport program

• Being on a ketogenic diet

• Any clinical abnomally in prescreen blood sample

Related Conditions & MeSH terms

• Ketoses, Metabolic
• Ketosis

Intervention

Radiation:
• Observational heart and kidney on siemens TEP scan
Same as arm description

Locations

Country	Name	City	State
Canada	Research Center on Aging	Sherbrooke	Quebec

Sponsors (2)

Lead Sponsor	Collaborator
Université de Sherbrooke	Nestlé Health Science Spain

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Mean in left ventricule myocradial blood flow	Heart acetate metabolism measured by TEP scan	30 minutes
Primary	Mean in left ventricule myocardial blood flow	Heart acetoacetate metabolism measured by TEP scan	30 minutes
Primary	Mean in Kidney acetate uptake	Kidney acetate uptake measured by TEP scan	30 minutes
Primary	Mean in Kidney acetoacetate uptake	Kidney acetoacetate uptake measured by TEP scan.	30 minutes