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Keratoconjunctivitis clinical trials

View clinical trials related to Keratoconjunctivitis.

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NCT ID: NCT02688556 Completed - Clinical trials for Keratoconjunctivitis Sicca

Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca

Emerald
Start date: February 2016
Phase: Phase 3
Study type: Interventional

This is a randomized, double-masked, vehicle-controlled study of the safety and efficacy of OTX-101 (0.09% cyclosporine nanomicellar solution) in the treatment of keratoconjunctivitis sicca to be conducted at approximately 50 sites.

NCT ID: NCT02680158 Completed - Dry Eye Syndrome Clinical Trials

A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye Syndrome

Start date: January 31, 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to compare acute tear production produced by the Oculeve Intranasal Lacrimal Neurostimulator with two control devices in participants with aqueous tear deficiency.

NCT ID: NCT02665234 Completed - Clinical trials for Keratoconjunctivitis Sicca

A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye Disease

Start date: January 2016
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of Tavilermide Ophthalmic Solution compared with Placebo Ophthalmic Solution in treating the signs and symptoms of dry eye disease.

NCT ID: NCT02634853 Completed - Clinical trials for Keratoconjunctivitis Sicca

A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye

Start date: December 2015
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of Tavilermide Ophthalmic Solution compared with Placebo Ophthalmic Solution in treating the signs and symptoms of dry eye.

NCT ID: NCT02526290 Completed - Dry Eye Syndromes Clinical Trials

Six Month Study to Evaluate the Safety and Effectiveness of the Intranasal Lacrimal Neurostimulator

Start date: August 31, 2015
Phase: N/A
Study type: Interventional

In this study, the safety and effectiveness of the Oculeve Intranasal Lacrimal Neurostimulator after 180 days of use in participants with aqueous tear deficiency will be evaluated.

NCT ID: NCT02456025 Recruiting - Clinical trials for Vernal Keratoconjunctivitis

Topical Tacrolimus in Vernal Keratoconjunctivitis

Start date: April 2013
Phase: Phase 4
Study type: Interventional

The main aim of this study is to evaluate the efficacy and safety of topical tacrolimus 0.01% eyedrops in patients with vernal keratoconjunctivitis.

NCT ID: NCT02424266 Not yet recruiting - Healthy Subjects Clinical Trials

Three Dimension Tomography of Eye Structures by White Light Imaging Device

3D-WLT
Start date: April 2015
Phase: N/A
Study type: Observational [Patient Registry]

The purpose of this study is to investigate the ability of an imaging device, developed by AdOM Advanced Optical Technologies Ltd. ("AdOM"). The device allows a three-dimensional imaging of the ocular tissues, specifically the tear film layers and the retinal layers. The device is based on the use of white light. In this initial study, the device will be used to assess the tear film which coats the corneal surface in healthy subjects as well as in moderate-to-severe Keratoconjunctivitis Sicca (KCS) or Dry Eye Syndrome (DES). The ability of the device to assess the retinal layers will be evaluated in the second phase of the study.

NCT ID: NCT02254265 Completed - Dry Eye Disease Clinical Trials

Phase 2/3 Dose-Ranging Study of the Safety and Efficacy of OTX-101 in the Treatment of Keratoconjunctivitis Sicca

Start date: September 2014
Phase: Phase 2/Phase 3
Study type: Interventional

This is a Phase 2/3 study to evaluate the safety and efficacy of 2 different dose concentrations of OTX-101 dosed twice a day in both eyes for 84 days compared to placebo (vehicle) in patients with keratoconjunctivitis sicca (dry eye disease).

NCT ID: NCT02188160 Completed - Dry Eye Syndromes Clinical Trials

Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease

Kauai
Start date: June 2014
Phase: Phase 2
Study type: Interventional

The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease. The product will be studied over 28 days, with 1-2 drops instilled in each eye four times daily (QID).

NCT ID: NCT02160327 Active, not recruiting - Dry Eye Clinical Trials

The Role of Cytokines and Mast Cell in the Pathogenesis of SLK, Conjunctivochalasis, and Dry Eye

Start date: March 2014
Phase: N/A
Study type: Observational

The specific aims of the the investigators studies are as follows: - To collect the tear samples from patients with different ocular surface disorders, including SLK, conjunctivochalasis, and keratoconjunctivitis sicca (KCS). - To evaluate the differential expression of tear cytokines and pH values between different ocular surface disorders. - To collect the surgical conjunctival specimens from the patients with SLK and conjunctivochalasis. - To evaluate the factors inducing mast cell migration and how mast cell is activated in SLK via surgical specimens and cultivated fibroblast.