Interleukin 33 in Juvenile Idiopathic Arthritis Patients

Status Completed

Clinical Trial Summary

The aim of this study is to measure serum and synovial fluid levels of IL 33 and its relative mRNA expression in peripheral blood mononuclear cells in juvenile idiopathic arthritis (JIA) patients and to correlate it with the clinical and laboratory characteristics, disease activity and musculoskeletal ultrasound findings.

Clinical Trial Description

SUBJECTS AND METHODS

Subjects:This study will be a case-control study including sixty children with juvenile idiopathic arthritis attending pediatric rheumatology clinic of Benha University Hospital and Benha children hospital and thirty apparently healthy children as controls. They will be classified into:

- Group (I) study group:60 cases of children with juvenile idiopathic arthritis.

- Group (II) Control group:60 of apparently healthy children matched for age and sex

A)Full history taking

B) Full clinical examination

C) Clinical assessment of disease activity

D) Laboratory Investigations:

All subjects will be investigated by

1. complete blood count.

2. Erythrocyte sedmentation rate.

3. C-reactive protein .

4. Liver enzymes: ALT and AST.

5. Rheumatoid factor.

6. Antinuclear antibody (ANA).

7. serum ferritin

8. serum and synovial fluid Interleukin 33 by ELISA and its relative expression in peripheral blood mononuclear cells by PCR

E) Musculoskeletal Ultrasound examination ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03835624
Study type	Observational
Source	Benha University
Contact
Status	Completed
Phase
Start date	February 12, 2019
Completion date	November 20, 2019

View Details

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