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NCT02505828 Clinical Trial

ARTEMIS Synovial Markers in Arthritis Childhood

Juvenile Idiopathic Arthritis Clinical Trial

— ARTEMIS  

Official title:
ARTEMIS Synovial Markers in Arthritis Childhood

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02505828
Other study ID # 93612
Secondary ID 2014-A01561-46
Status Completed
Phase N/A
First received
Last updated
Start date April 2015
Est. completion date April 2018

Study information
Verified date December 2020
Source University Hospital, Montpellier
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of this study is to find markers that could differentiate infectious and inflammatory arthritis. The investigators want to find markers by differential analysis by compare synovial fluids of septic and inflammatory arthritis. The investigators will use for this analysis, proteomics, cytokine dosage and monocyte typing by flow cytometry analysis. The investigators will use one marker or a score with biological and clinical data to discriminate arthritis of infectious and inflammatory etiology.

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date April 2018
Est. primary completion date April 2018
Accepts healthy volunteers No
Gender All
Age group 6 Months to 18 Years
Eligibility Inclusion Criteria: - Septic arthritis with bacteriological identification - Juvenile idiopathic arthritis beyond the ILAR definition - Having acute arthritis requiring an articular draining - Child benefiting from a national insurance scheme - Collection of the consent of the parents or the legal representative Exclusion Criteria: - Contraindication in an articular draining: platelet 50 000 / mm3, Rate of prothrombins lower than 70 %, activated partial thromboplastin times (APTT)> 1,5 - Treatment by biotherapy, corticoids or other immuno suppressor in the month preceding the articular draining. - Treatment by antibiotic begun more than 24 hours before the draining.

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Articular punction, salivary samples, blood sample

Locations
Country Name City State
France Hôpital Arnaud de Villeneuve Montpellier

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

References & Publications (2)

Cren M, Nziza N, Carbasse A, Mahe P, Dufourcq-Lopez E, Delpont M, Chevassus H, Khalil M, Mura T, Duroux-Richard I, Apparailly F, Jeziorski E, Louis-Plence P. Differential Accumulation and Activation of Monocyte and Dendritic Cell Subsets in Inflamed Synov — View Citation

Nziza N, Jeziorski E, Delpont M, Cren M, Chevassus H, Carbasse A, Mahe P, Abassi H, Joly-Monrigal P, Schordan E, Mangé A, Jorgensen C, Apparailly F, Duroux-Richard I. Synovial-Fluid miRNA Signature for Diagnosis of Juvenile Idiopathic Arthritis. Cells. 20 — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Qualitative analysis of new biological markers (proteic, cytokine or cellular) that discriminate inflammatory and infectious arthritis. Identify blood sampling biomarkers of Arthritis childhood 1 day
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