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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT02218892
Other study ID # 2010/2089-31/2
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date February 2011
Est. completion date December 2023

Study information

Verified date March 2023
Source Folktandvården Stockholms län AB
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Purpose and aims The general aim of this project is to improve the diagnostic methods for disease activity and identify predictive factors (clinical and radiographic factors, pro- and anti-inflammatory mediators in saliva and plasma) for temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA). The hypothesis is that self-reported pain and impaired jaw function together with clinical findings correlates well with radiological signs of jaw involvement. Null hypothesis: Self-reported pain, impaired jaw function and clinical findings do not correlate with radiological signs of jaw involvement. Study 1 The aim of this study is to investigate which findings from the patient history and from clinical examination that is of significance for diagnostics of TMJ involvement in patients with JIA both in a short- and long-term perspective. The patients will be followed-up during two years. They will undergo a clinical examination according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD; Dworkin and LeResche 1992) once a year and a telephone follow-up sixth months after the clinical examination. Further, the clinical findings from the orofacial regions will be compared to their general disease activity. Study 2 The aim of the second study is to correlate radiological findings and clinical findings in order to investigate any early radiological signs of disease activity and progression but also to compare the radiographic examination using conventional panoramic technique with computer tomography (CT).


Description:

One-hundred consecutive patients with active JIA, as diagnosed by the Department of Pediatric Rheumatology, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital will be included. Inclusion criteria are: - age between 7 and 14 years - a diagnosis of JIA according to the International League of Associations for rheumatology Exclusion criteria are: - current malignancies - TMJ surgery or trauma within two years - recent intra-articular glucocorticoid injection in TMJ (within 1 month) - other conditions or diseases than JIA that may cause orofacial pain. The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1. Clinical examination and follow-ups The patients will be examined clinically three times with an interval of 12 months. The clinical examination will be performed according to the RDC-TMD by calibrated investigators. Panoramic x-ray and CT scans will be performed at the inclusion examination as well as at the end of the study after 24 months. Pharmacological treatment will be recorded at every clinical examination and at telephone interviews. The patients will also be examined by a pediatric rheumatologist regarding general disease activity according to the Juvenile Arthritis Disease Activity Score 27 (JADAS-27), the Short Form (36) Health Survey (SF-36), thrombocyte particle count, C-reactive protein and blood titer of rheumatoid factor and anti-cyclic citrullinated peptides. Information from the examination by the pediatric rheumatologist will be drawn from the Swedish national register for children with JIA. Telephone interview Six months after the first and second visit, a structured telephone interview with the patients and/or their parents will be performed according to a questionnaire. The objective is to estimate the degree of joint pain and functional limitations in jaw function. Radiological examination Conventional panoramic x-rays and bilateral TMJ images will be obtained with the digital volume tomography (DVT, New Tom Model QR-DVT 9000, New Tom AG, Marburg, Germany). The CT sections will be evaluated by a specialist in oral radiology for presence of radiographic signs of cortical and subcortical erosions, flattening, sclerosis and ramus height.


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 62
Est. completion date December 2023
Est. primary completion date August 2017
Accepts healthy volunteers No
Gender All
Age group 7 Years to 14 Years
Eligibility Inclusion Criteria: 1. age between 7 and 14 years 2. a diagnosis of JIA according to the International League of Associations for rheumatology (ILAR) The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1. Exclusion Criteria: 1. current malignancies 2. TMJ surgery or trauma within two years 3. recent intra-articular glucocorticoid injection in TMJ (within 1 month) 4. other conditions or diseases than JIA that may cause orofacial pain.

Study Design


Locations

Country Name City State
Sweden Folktandvården Stockholmslän AB Stockholm

Sponsors (2)

Lead Sponsor Collaborator
Malin Collin Karolinska Institutet

Country where clinical trial is conducted

Sweden, 

Outcome

Type Measure Description Time frame Safety issue
Primary Clinical findings in children with JIA To find similarities in patients with JIA according to RDC-TMD (a clinical protocol validated for children) 2 years
Primary Radiographic findings in children with JIA Repeated radiographic examination Two years
Primary Patient history Repeated interview on function and pain in the jaw area Two years
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