Direct Thawing of Vitrified Human Blastocyst

IVF Clinical Trial

Official title:

A Pilot Study on Developing a One-step Direct Thawing Method on Human Blastocysts With Transcriptomic and Methylomic Comparison to Conventional Vitrified-thawing Method

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06322823
• Other study ID #: 2010.432
• Status: Completed
• Phase: N/A
• Start date: January 1, 2020
• Est. completion date: December 31, 2023

Study information

• Verified date: March 2024
• Source: Chinese University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

There are more than million frozen embryo transfers around the world each year; a faster, safer, and cheaper method can save a significant amount of money for patients undergoing IVF treatment worldwide.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 116
• Est. completion date: December 31, 2023
• Est. primary completion date: December 31, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Patients who are willing to use direct-thawed blastocysts

Exclusion Criteria:

• Patients who are not willing to use direct-thawed blastocysts

Related Conditions & MeSH terms

• IVF

Intervention

Procedure:
• direct thawing
Vitrified blastocysts will be thawed directly into 1ml G-TL medium
• Vitrification
Vitrified blastocysts will be thawed using commercially available one-step media.

Locations

Country	Name	City	State
Hong Kong	David Yiu Leung Chan	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
Chinese University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	blastocysts survival rate	The overall survival rate for thawed blastocysts using different thawing method will be compared.	up to 6 months
Secondary	ferilization rate	The fertilization rate of frozen embryos using different thawing methods will be compared.	up to 12 months
Secondary	pregnancy rate	The pregnancy rate of patients who will be scheduled for the transfer of frozen embryos using different thawing methods will be compared.	up to 12 months
Secondary	live birth rate	The live birth rate of patients who will be scheduled for the transfer of frozen embryos using different thawing methods will be compared.	up to 24 months