Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes

IVF Clinical Trial

Official title:

"Effect of Tadalafil, Sildenafil and Pentoxyfylline on Endometrial Thickness and Frozen Embryo Transfer Outcomes

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05971667
• Other study ID #: Tadalafil IVF
• Status: Not yet recruiting
• Phase: Phase 2/Phase 3
• Start date: July 30, 2023
• Est. completion date: October 30, 2023

Study information

• Verified date: August 2023
• Source: Beni-Suef University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization. In addition, the thickness of endometrium and pregnancies rates of these women will also be examined. All adverse effects of all drugs will be estimated

Description:

A prospective randomized clinical study will be conducted in the IVF clinic of the gynecology department of Beni Suef University Hospital, Beni-Suef, Egypt. The study will These patients will be randomized into four groups.

The participants will take drugs starting from the end of menstruation cycle till endometrium reach optimal and then will start progesterone 800 mg daily.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 200
• Est. completion date: October 30, 2023
• Est. primary completion date: October 30, 2023
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• women having thawed embryos

Exclusion Criteria:

• hypotension

• cardiovascular, hepatic, and renal diseases;

• uncontrolled diabetes mellitus;

• ovarian cysts;

• hyperprolactinemia;

• abnormal thyroid functions;

• uterine fibroids;

• patients taking nitrates;

• endometriosis and adenomyosis

Related Conditions & MeSH terms

• IVF

Intervention

Drug:
• tadalafil
tadalafil 10 mg one tablet daily
• Sildenafil
sildenafil 20 mg two tablets daily
• pentoxifylline
pentoxifylline 400 mg two tabs daily

Locations

Country	Name	City	State
Egypt	Beni-suef university Hospital	Bani Suwayf	Beni Suef

Sponsors (1)

Lead Sponsor	Collaborator
Beni-Suef University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	endometrial thickness	measured by transvaginal ultrasound	within 16 day of menstruation
Secondary	pregnancy rate	number of cases positive serum pregnancy test	1 month