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The Zambia Ivermectin Trial for the Treatment and Prevention of COVID-19 — ZIT  

SARS-CoV-2 Clinical Trial

Official title:
The Zambia Ivermectin Trial for the Treatment and Prevention of COVID-19

Clinical Trial Summary

The study aims to test whether Ivermectin would decrease mortality and reduces chances of getting infected with corona virus, improve management of clinical symptoms and reduce length of stay in ICU and transition probabilities to ICU (ventilator).

Clinical Trial Description

With the onset of global pandemic of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the sharp rise in infection and mortality rates, efficient management of the current medical emergency has become an absolute priority. A lot of resources have been directed to developing a comprehensive therapeutic approach to preventing and curing this disease, and this has mostly been in western countries. However, lack of definite treatment, high number of infected people, limited capacity and the impact of COVID-19 on existing health infrastructure has left biomedical researchers and clinicians faced with the mammoth task of providing appropriate clinical care solutions and strategies with favorable cost-benefit outcomes, which can help in both curbing the disease and treating patients. To meet this challenge, repurposing of available drugs has become vital. Evidence from several recent clinical trials on the effects of available therapeutic clinical drugs and vitamin supplements on mortality rate and other clinical outcomes associated with COVID-19 are promising, however, the efficacy, safety, and appropriate dosing of therapeutic clinical drugs such as ivermectin, remain largely unevaluated in Sub-Saharan Africa. The investigators propose to evaluate and compare the efficacy of ivermectin in the management of Covid-19. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04891250
Study type Interventional
Source Centre for Infectious Disease Research in Zambia
Contact
Status Withdrawn
Phase Phase 4
Start date October 2021
Completion date June 2022
View Details
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