Itching Clinical Trial
Official title:
A Pilot Study to Determine the Pruritic Benefits of Ondansetron Versus Diphenhydramine in Burn Patients Undergoing Wound Healing
The purpose of this study is to see if a drug called ondansetron (Zofran) controls itching from healing burn wounds as well or better than the usual drug used, diphenhydramine (Benadryl).
A clear mechanism or cause for pruritus in patients recovering from burn has not been
delineated.
While the exact mechanisms/pathways for itching are currently unclear, histamine antagonism
appears to be the most popular treatment. Whether histamine antagonism works predominantly
via peripheral inhibition or central sedation is uncertain. By treating another intermediary
in the pruritus cascade, it may be possible that an alternate treatment could be used while
eliminating some of the unwanted side effects of antihistamine at the same time.
;
Allocation: Randomized, Endpoint Classification: Bio-equivalence Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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