Itch Clinical Trial
Official title:
A Mechanistic Study on Morphine-induced Orthogonal Neural Plasticity for Itch and Pain Processing in Humans (a Relation of Morphine-induced Itch and Pain Processing)
In This experiment, the investigators would like to test the two following hypotheses
regarding the mechanisms by which opioids cause itch:
1. Opioids cause itch by a spinal disinhibition mechanism (central nervous system (CNS)
effect).
2. Opioids cause itch through a mast cell-destabilizing effect leading to release of
histamine and tryptase in the skin where itch is evoked (peripheral mechanism).
Intrathecal and orally administered opioids are heavily used for the treatment of several
acute pain conditions. However, while opioids are effective analgesics for acute pain, they
are well-known to frequently cause itch (pruritus) as a side effect according with the two
hypotheses stated above. So far, these two hypotheses have never been tested in humans.The
present study describes a proposed study design for the purpose of confirming these two
hypotheses in parallel in human subjects.
Primary endpoints of the study:
To evaluate changes itch and pain perception, and superficial perfusion after each itch
provocations.
Secondary endpoints of the study:
To evaluate the existence of a correlation between itch sensitization and analgesic efficacy.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01683552 -
Aprepitant in the Management of Biological Therapies-related Severe Pruritus
|
Phase 2 | |
| Completed |
NCT02075632 -
Study to Evaluate Product Duration of Use Experience With Alclometasone Dipropionate Cream
|
Phase 2 | |
| Completed |
NCT04515056 -
Characterization of New Human Models of Non-histaminergic Itch
|
N/A | |
| Completed |
NCT04076865 -
Evaluation of the Effect Induced by Repeated Administration of Topical Local Anaesthetic (EMLA) on Itch
|
N/A | |
| Completed |
NCT04588532 -
Characterization of BAM8-22 as a New Surrogate Model of Non-histaminergic Itch
|
N/A | |
| Enrolling by invitation |
NCT05195177 -
Testing Protocol to Efficiently Induce Itch
|
N/A | |
| Withdrawn |
NCT03943407 -
Characterization of the Toll-like Receptor 7-agonist Imiquimod 3.75% as a New Surrogate Model of Itch
|
N/A | |
| Completed |
NCT04858360 -
Inhibition of Non-histaminergic Pruritus Applied Using 3 Different Pruritogens
|
N/A | |
| Completed |
NCT04635254 -
The Effect of Halophyte-based Cream on Pain and Itch
|
N/A | |
| Not yet recruiting |
NCT06201715 -
Efficacy and Safety of Tofacitinib in Patients With Prurigo Nodularis
|
N/A | |
| Completed |
NCT06036589 -
Characterization of Bovine Adrenal Medulla as a Model of Non-histaminergic Itch
|
N/A | |
| Completed |
NCT04554888 -
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor
|
N/A | |
| Completed |
NCT04387851 -
Learning Mechanisms for Placebo and Nocebo Studies on Somatosensory Sensations: a Systematic Review and Meta-analysis.
|
||
| Completed |
NCT03928223 -
The Color of Itch; Itch Modification by Color Viewing
|
||
| Not yet recruiting |
NCT06245564 -
Effect of Ketamine, Amitriptyline and Their Combination on Histaminergic and Non-histaminergic Itch
|
N/A | |
| Completed |
NCT03576053 -
A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing
|
N/A | |
| Completed |
NCT04700007 -
Evaluation of Peripheral Itch Mechanisms Following Injection of Morphine (Second Sub-Project)
|
N/A | |
| Terminated |
NCT02828787 -
Central Mechanisms of Chronic Pruritus: Functional and Structural Brain Imaging.
|
N/A | |
| Not yet recruiting |
NCT04197440 -
Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch
|
N/A | |
| Completed |
NCT05249387 -
Characterization of Bovine Adrenal Medulla as a New Surrogate Model of Non-histaminergic Itch
|
N/A |