Itch Clinical Trial
Official title:
Characterization of the Toll-like Receptor 7-agonist Imiquimod 3.75% as a New Surrogate Model of Itch
The aim of this research project is to design a new model of human itch by application of Zyclara cream. Further, the aim is to characterize the model and to verify if the mechanism of action of imiquimod follows the histaminergic or non-histaminergic pathway by using the anti-histamine drug doxepin. The last goal is to evaluate the interaction between the activation of TLR7 receptor and the activation of TRPA1 and TRPM8 receptors, which are two of the most important receptors involved in the transduction of noxious stimuli, and to evaluate to which extent these three channel populations functionally overlap.
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Status | Clinical Trial | Phase | |
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Completed |
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Not yet recruiting |
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Completed |
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Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor
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Completed |
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Learning Mechanisms for Placebo and Nocebo Studies on Somatosensory Sensations: a Systematic Review and Meta-analysis.
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Completed |
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The Color of Itch; Itch Modification by Color Viewing
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Not yet recruiting |
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N/A | |
Completed |
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Completed |
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N/A | |
Terminated |
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N/A | |
Not yet recruiting |
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Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch
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N/A | |
Completed |
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Completed |
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N/A |