Clinical Trials Logo

Clinical Trial Summary

Islet transplantation for type 1 diabetes results are still improving, and actually Insulin-independence with normal HbA1c is obtained in 50% of patients after 5 years, 80% of c-peptide positive patients. In addition to the need of 2 or 3 surgical or radiological interventions to inject islets, an immunosuppressive regimen is needed, which can be deleterious, particularly on kidneys. Moreover, long term beneficial effects of islet transplantation on stabilization or prevention of macro and micro vascular complications of diabetes has not been evaluated. In a preliminary work, it was observed a stabilisation or improvement of microvascular complications when compared to pre-transplant data. The aim of this study is to compare the evolution of diabetes complications, especially nephrologic, 10 years after islet transplantation and to compare it to patients with a brittle diabetes, 10 years after evaluation for islet transplantation, finally not performed. This case-control study will evaluate nephrologic parameters (creatinine, MDRD creatinine clearance, microalbuminuria, proteinuria) and other micro and macro-vascular complications of type 1 diabetes) before islet transplantation and 10 years after the transplantation or after the first evaluation in patients who finally did not underwent islet transplantation for various non nephrologic reasons


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02627690
Study type Observational
Source University Hospital, Lille
Contact
Status Completed
Phase
Start date November 3, 2014
Completion date November 29, 2021

See also
  Status Clinical Trial Phase
Withdrawn NCT01123122 - A Comparison of Strict Glucose Control With Usual Care at the Time of Islet Cell Transplantation N/A
Completed NCT00417131 - Imaging of Islet Transplantation With PET and MRT N/A
Not yet recruiting NCT05973734 - Islet Transplantation With Recipient T-Reg Cells or Deceased Donor Vertebral Bone Marrow Therapy Phase 1
Completed NCT01369082 - Extended Follow-Up After Islet Transplantation in T1D N/A
Terminated NCT00853944 - Effect of Sitagliptin on Graft Function Following Islet Transplantation Phase 3
Completed NCT03427931 - CGM Use in Islet Transplant Recipients N/A
Terminated NCT00409461 - Comparison of Sirolimus Alone With Sirolimus Plus Tacrolimus in Type 1 Diabetic Recipients of Cultured Islet Cell Grafts N/A