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Islet Transplantation clinical trials

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NCT ID: NCT05973734 Not yet recruiting - Clinical trials for Islet Transplantation

Islet Transplantation With Recipient T-Reg Cells or Deceased Donor Vertebral Bone Marrow Therapy

Start date: October 1, 2023
Phase: Phase 1
Study type: Interventional

The goal of this clinical trial is to learn if patients who have brittle type 1 diabetes receiving an islet transplantation will have better control of their sugars if they also receive one of 2 types of immune cells along with the islet transplant. The participants will receive either their own immune cells, called regulatory T cells, or immune cells from the bone marrow of the islet donor.

NCT ID: NCT03427931 Completed - Clinical trials for Type1 Diabetes Mellitus

CGM Use in Islet Transplant Recipients

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

A study assessing glucose variability in subjects with Type 1 Diabetes who have had islet transplant.

NCT ID: NCT02627690 Completed - Clinical trials for Islet Transplantation

Nephrologic Prognosis 10 Years After Diabetes Cell Therapy

PRONOCELDIAB
Start date: November 3, 2014
Phase:
Study type: Observational

Islet transplantation for type 1 diabetes results are still improving, and actually Insulin-independence with normal HbA1c is obtained in 50% of patients after 5 years, 80% of c-peptide positive patients. In addition to the need of 2 or 3 surgical or radiological interventions to inject islets, an immunosuppressive regimen is needed, which can be deleterious, particularly on kidneys. Moreover, long term beneficial effects of islet transplantation on stabilization or prevention of macro and micro vascular complications of diabetes has not been evaluated. In a preliminary work, it was observed a stabilisation or improvement of microvascular complications when compared to pre-transplant data. The aim of this study is to compare the evolution of diabetes complications, especially nephrologic, 10 years after islet transplantation and to compare it to patients with a brittle diabetes, 10 years after evaluation for islet transplantation, finally not performed. This case-control study will evaluate nephrologic parameters (creatinine, MDRD creatinine clearance, microalbuminuria, proteinuria) and other micro and macro-vascular complications of type 1 diabetes) before islet transplantation and 10 years after the transplantation or after the first evaluation in patients who finally did not underwent islet transplantation for various non nephrologic reasons

NCT ID: NCT01369082 Completed - Clinical trials for Islet Transplantation

Extended Follow-Up After Islet Transplantation in T1D

Start date: May 2011
Phase: N/A
Study type: Observational

The purpose of this study is to provide patients who have received at least one islet transplant as a previous participant in a Clinical Islet Transplantation Consortium (CIT) clinical trial with maintenance immunosuppressive medications and to collect information about the safety of the medications and islet function.

NCT ID: NCT01123122 Withdrawn - Clinical trials for Diabetes Mellitus, Type 1

A Comparison of Strict Glucose Control With Usual Care at the Time of Islet Cell Transplantation

Start date: September 2011
Phase: N/A
Study type: Interventional

Islet transplants for those with type 1 diabetes have enabled many to initially eliminate insulin, however, only a fraction of the transplanted cells typically survive and the functioning of these decrease over time. As a result, most patients will eventually require some insulin. Currently, the cause of this poor survival and decrease in function is not understood; although previous research has demonstrated that even a slightly elevated level of blood glucose can impair islet function. This study will determine if strict blood glucose control at the time of islet transplantation, when the cells are the most fragile, will improve the survival and functioning of transplanted islet cells three months after transplantation.

NCT ID: NCT00853944 Terminated - Clinical trials for Islet Transplantation

Effect of Sitagliptin on Graft Function Following Islet Transplantation

Start date: July 2009
Phase: Phase 3
Study type: Interventional

Islet transplantation requires a large number of islets required to achieve insulin independence and the function of the transplanted islets progressively declines over time. Evidence from animal studies and human islets in culture suggests that increasing GLP-1 levels could help with both of these problems. This study is designed to test this hypothesis using sitagliptin in a randomized clinical trial.

NCT ID: NCT00417131 Completed - Diabetes Type 1 Clinical Trials

Imaging of Islet Transplantation With PET and MRT

Start date: October 2006
Phase: N/A
Study type: Observational

Islets of Langerhans intended for clinical transplantation are labelled with a radioactive tracer. The tracer is retained in viable cells of the transplant. At infusion (transplantation) of the islets into the portal vein the tracer can be followed for two hours with positron emission tomography (PET). Imaging and calculations can give estimates of the proportion of surveying islets and the rate of early destruction. Also the distribution of the islets into the liver can be viewed.

NCT ID: NCT00409461 Terminated - Type 1 Diabetes Clinical Trials

Comparison of Sirolimus Alone With Sirolimus Plus Tacrolimus in Type 1 Diabetic Recipients of Cultured Islet Cell Grafts

Start date: n/a
Phase: N/A
Study type: Interventional

Proof of concept study in islet transplantation, two treatment arms (ATG SIR-TAC versus ATG SIR) each consisting of ten type 1 diabetic patients