Ischemic Preconditioning Clinical Trial
Official title:
Effects of Remote Ischemic Preconditioning on Components of Peripheral Blood and Gut Microbiome (EMINENT): a Single-centre, Open-label, Randomized Controlled Trial
The aim of this study is to investigate the effects of remote ischaemic preconditioning on the peripheral blood characteristics of healthy adults and to explore the possible mechanisms for improving ischaemia/reperfusion injury and its protective effects on the cardiovascular system.
This study will recruit 40 healthy individuals and randomly assign them to group A or B to undergo remote ischaemic preconditioning training for 7 consecutive days, and routine biological specimens from subjects before and after the intervention will be collected. Participants in group A will be trained once a day, while those in group be will be trained twice a day. The characteristics of different fractions of blood and urine and fecal specimens from subjects at different time points before and after ischaemic preconditioning will be examined to investigate the effects of remote ischaemic preconditioning on the characteristics of peripheral blood, urine and feces in healthy adults. It also provides evidence for improving the efficiency of clinical transfusion and blood conservation by comparing the differences in blood fractions under different preservation conditions. ;
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