Clinical Trials Logo
  1. Home
  2. Ischemic Preconditioning
  3. NCT01164618

The Biology of Chronic Preconditioning: Genomic and Physiologic Mechanisms of Response

Ischemic Preconditioning Clinical Trial

Official title:
The Biology of Chronic Preconditioning: Genomic and Physiologic Mechanisms of Response

Clinical Trial Summary

The purpose of this study is to assess the effects of repeated RIPC and exercise, on exercise performance, skeletal muscle responses and circulating cellular and humoral biology in humans

Clinical Trial Description

Remote ischemic preconditioning (RIPC) results in a powerful and widespread protective effect against subsequent prolonged ischemia-reperfusion (IR) injury of distant organs and systemic inflammatory responses, both of which are key elements in the evolution of local and multiorgan effects of many clinical IR syndromes. The signal transduction within the target organ to generate ischemia tolerance, and the effects of RIPC on systemic anti-inflammatory pathways, however, remain to be elucidated fully. Particularly, data regarding the mechanisms of 'second window' protection (a resurgence of protection 24-72 hrs after the initial RIPC stimulus) is scant; even less is known of the effects of repeated RIPC, and a potential 'third window' of protection. Our preliminary data and several recent publications have shown that the biology of RIPC and exercise show considerable overlap. This research has raised the possibility of a reciprocal effect between RIPC and exercise, with chronic exercise being a model of the potential effects of 'chronic preconditioning'. This is relevant, as repeated RIPC might be a strategy to improve exercise function in those with limited exercise tolerance e.g. heart failure. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01164618
Study type Interventional
Source The Hospital for Sick Children
Contact
Status Active, not recruiting
Phase Phase 2
Start date May 2010
Completion date January 2014
View Details
See also
  Status Clinical Trial Phase
Completed NCT01235286 - Cutaneous Remote Ischemic Preconditioning in Plastic Surgery N/A
Completed NCT01118000 - Study on the Cardioprotection and Humoral Mechanism of Limb Ischemia Preconditioning N/A
Completed NCT00184912 - The Effect of Caffeine on Ischemic Preconditioning N/A
Recruiting NCT03380663 - Conditioning Based Intervention Strategies N/A
Completed NCT03023150 - Ischemic Preconditioning as an Intervention to Improve Stroke Rehabilitation - Froedtert N/A
Completed NCT02981680 - Effect of Remote Ischemic Preconditioning on the Incidence of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft Surgery N/A
Completed NCT00821522 - The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery Phase 1
Not yet recruiting NCT05957523 - Effects of Remote Ischemic Preconditioning on Components of Peripheral Blood and Gut Microbiome (EMINENT) N/A
Completed NCT04887610 - Factors That Influence Blood Vessel Regulation During Exercise in Humans N/A
Completed NCT05219344 - Tissue Flossing and Lower Limb Neuromuscular Function N/A
Completed NCT00453531 - Model System for Transient Forearm Blood Vessel Dysfunction Phase 1/Phase 2
Not yet recruiting NCT05412888 - Effect of CoQ10 on the Endocrine Function of Skeletal Muscle N/A
Recruiting NCT03900390 - The Study of Potency of Cross-preconditioning to Prevent Ischemic-reperfusion Injury for Heart Transplantation Recipient N/A
Completed NCT02411266 - Preconditioning With Limb Ischemia for Subarachnoid Hemorrhage N/A
Completed NCT02666235 - Remote Ischaemic Conditioning and Coronary Endothelial Function (RIC-COR) Phase 2
Terminated NCT01743937 - A Trial Comparing the Ischemic Preconditioning Effects of Ticagrelor and Clopidogrel in Humans Phase 4
Completed NCT04016857 - Remote Ischemic Preconditioning During Lower Limb Revascularization N/A
Not yet recruiting NCT05653505 - Remote Ischemic Conditioning Combined With Endovascular Stenting for Symptomatic Intracranial Atherosclerotic Stenosis
Completed NCT02965547 - Remote Ischemic Preconditioning of Dynamic Cerebral Autoregulation in Healthy Adults N/A
Completed NCT05350683 - Effect of Remote Ischemic Preconditioning on the Incidence of Contrast Induced Nephropathy in Patients Undergoing EVAR Phase 2