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Ischemic Leg clinical trials

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NCT ID: NCT04746599 Recruiting - Diabetic Foot Clinical Trials

Autologous Fat Grafting in the Treatment of Critical Limb Ischaemia

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Critical Limb Ischaemia (CLI) is a condition characterized by chronic ischemic at-rest pain, ulcers, or gangrene for more than 2 weeks in one or both legs, attributable to objectively proven arterial occlusive disease.CLI is associated with a high risk of lower amputation, diminished quality of life and mortality. Revascularization by either bypass surgery or endovascular recanalization is considered the first-choice treatment in patients with CLI. Revascularization is not always possible because patients with CLI often have severe comorbidities or because it is not technically feasible. On the basis of their well-recognized regenerative and angiogenetic properties, cell therapy with autologous bone marrow-derived mesenchymal stem cells (BMMSCs) has been proposed and tested in different animal models and in some human pathological conditions characterized by peripheral ischemia and wound formation.

NCT ID: NCT04434586 Recruiting - Claudication Clinical Trials

Contribution of Optical Coherence Tomography in the Endovascular Treatment of Femoral Occlusions

TOCAF
Start date: June 16, 2020
Phase: N/A
Study type: Interventional

This is a common care study. A study for evaluating the quality of balloon inflation and stent application will be performed in 2D angiography alone in the control group and then by 2D and OCT angiography for the experimental group. The benefit could be an improvement in the results of revascularization of femoropopliteal lesions thanks to OCT which allows a 3D visualization of the arterial lumen.