Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion

Ischemia/Reperfusion Injury Clinical Trial

Official title:

Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00526695
• Other study ID #: 17-2005
• Status: Recruiting
• Phase: Phase 4
• First received: August 27, 2007
• Last updated: July 17, 2008
• Start date: January 2005
• Est. completion date: December 2008

Study information

• Verified date: July 2008
• Source: University of Zurich
• Contact: 01 Studienregister MasterAdmins
• Phone: +41 (0)44 255 11 11
• Is FDA regulated: No
• Health authority: Switzerland: Swissmedic
• Study type: Interventional

Clinical Trial Summary

Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury.

Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation

Description:

Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations.

Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 10
• Est. completion date: December 2008
• Est. primary completion date: December 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 25 Years to 45 Years

Eligibility

Inclusion criteria: male

• Non-smoker

• No asthma

• NPO

• Volunteer

Exclusion criteria:

• Female

• Chronic medication

• Asthma

• Smoking

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Ischemia
• Ischemia/Reperfusion Injury
• Reperfusion Injury

Intervention

Drug:
• Sevoflurane (Preconditioning)
Inhalation of sub-anesthetic doses of sevoflurane

Locations

Country	Name	City	State
Switzerland	University Hospital of Zurich	Zurich

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	marker expression on blood cells		December 2008	No