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Irritable Mood clinical trials

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NCT ID: NCT06133231 Not yet recruiting - Clinical trials for Attention Deficit/Hyperactivity Disorder

Optimizing Research With Diverse Families

Start date: September 2024
Phase: N/A
Study type: Interventional

Evaluate feasibility and acceptability of recruiting Black and Hispanic families for an open label clinical trial of micronutrients while collecting real-time parent-reported child behavior data and collecting at-home biospecimens to explore their potential as biomarkers, in a study of pediatric ADHD.

NCT ID: NCT06020261 Not yet recruiting - Anger Clinical Trials

Parent Management Training to Treat Irritability

PMT
Start date: December 15, 2023
Phase: N/A
Study type: Interventional

This is a pilot study to determine if the investigator can accrue a diverse sample of 30 children with significant irritability, conduct manualized Parent Management Training (PMT) with this group and measure physiology during pre- and post- PMT visits. The investigator will also aim to demonstrate the initial efficacy of PMT for irritability and utilize this trial to serve as a standard of care comparison for future studies.

NCT ID: NCT05974241 Completed - ADHD Clinical Trials

Irritability in Children With ADHD and Emotion Dysregulation

Start date: April 21, 2017
Phase: Phase 4
Study type: Interventional

Objective: Emotion dysregulation is common among children with ADHD and associated with a broad range of adult psychopathology, which is similar to the longitudinal outcomes of childhood irritability. However, the profiles of irritability in children with ADHD and emotion dysregulation has been understudied. This study aimed to investigate the efficacy of methylphenidate and aripiprazole in the treatment of irritability in children with ADHD and emotion dysregulation. In addition, the clinical profiles and neuropsychological characteristics of irritability in children with ADHD were explored.

NCT ID: NCT05930886 Recruiting - Clinical trials for Attention Deficit/Hyperactivity Disorder

Focus Groups in Ethnically and Racially Diverse Families

Start date: April 15, 2023
Phase:
Study type: Observational

Focus groups to identify treatment needs and barriers to participation in the planned multinutrient study among racially and ethnically diverse (Black and Hispanic) communities.

NCT ID: NCT05528926 Recruiting - Irritable Mood Clinical Trials

RESist Against Irritability Superiority Trial

RESIST
Start date: April 25, 2023
Phase: N/A
Study type: Interventional

Irritability is defined as developmentally inappropriate proneness to anger. Irritability is a symptom of several mental health conditions in children and adolescents such as attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), conduct disorder (CD), depressive disorders, anxiety disorders.Irritability has been associated with poor functional outcomes across the lifespan and was found to be specifically associated with concurrent and longitudinal emotional disorders, suicidality and impaired academic and socio-professional functioning. Children with high irritability also have distinct physiological profiles with hyper-reactivity to stress and perceived threats. Despite the high prevalence and health issues related to irritability, there is little treatment research on this topic. Developing evidence-based non-pharmacological treatment options for children suffering from severe, chronic irritability is therefore a particularly important target for clinical research.

NCT ID: NCT05414708 Recruiting - PTSD Clinical Trials

Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

Art therapy is used across the Military Health System for treatment of posttraumatic symptoms, but there is limited research on how art therapy is able to restore emotional expression and regulation in service members. This research hopes to learn about the effects of art therapy on emotional expression and regulation in service members as well as the neurological systems at work. If a participant chooses to be in this study, he or she will attend ten sessions over a period of twelve weeks. The first session will be an interview and self-assessment questionnaires to collect information on a variety of symptoms, experiences, and personality traits, and an MRI scan. During the MRI scan, participants will be asked to perform a task where they will be shown a series of neutral and negative images. The middle eight sessions will be one-hour art therapy sessions with a certified art therapist. The last session will consist of the same self-assessment questionnaires and another MRI scan.

NCT ID: NCT05388656 Recruiting - Menopause Clinical Trials

Estrogen Variability and Irritability During the Menopause Transition

Start date: June 15, 2022
Phase: Phase 4
Study type: Interventional

Women in the menopause transition (perimenopause) experience substantial day-to-day variability in estradiol and have a 2-4-fold increase in major depression risk. About 40% of perimenopausal women are susceptible to the emergence of affective symptoms tied to changes in estradiol. Among the perimenopausal women with affective impairment, most report irritability, not "depression," is their primary source of impairment and distress. The purpose of this research is to determine the neurophysiologic basis of susceptibility to estradiol fluctuations and irritability symptoms in perimenopausal women.

NCT ID: NCT05260398 Active, not recruiting - Clinical trials for Emotional Regulation

Examining the Impacts on In-School Behaviors of In-Home Videogame Play

Start date: February 28, 2022
Phase: N/A
Study type: Interventional

The proposed study aims to investigate the effects of children's in-home engagement with a biofeedback video game-based intervention on children's in-school behaviors. For the proposed study, families with no prior Mightier exposure will engage in online gameplay for eight weeks. Mightier will recruit families through social media and clinical settings, then Mightier will randomly assign participants to one of two groups: a group in which the child participant is encouraged to play Mightier games with biofeedback elements 45 or more minutes a week, broken into 3 or more sessions a week soon after baseline data have been collected, and a group in which the child participant receives Mightier and is invited to play Mightier games with biofeedback elements after all study baseline and follow-up data have been collected. The investigators will aim to enroll 20 parent-child dyads in each group. Specific Aims and Hypotheses: 1. Demonstrate that child engagement in Mightier biofeedback video games is correlated to child improvement in school behaviors. The investigators hypothesize that teachers of child participants will report reductions in child school behavior challenges after 8 weeks of child Mightier gameplay. 2. Demonstrate that child engagement in Mightier biofeedback video games is correlated to child improvement in at-home behaviors and general improvement in emotion regulation. The investigators hypothesize that parents of child participants will report a reduction in child behavior challenges and improvements in child emotion regulation after 8 weeks of child Mightier gameplay.

NCT ID: NCT05043805 Enrolling by invitation - Irritable Mood Clinical Trials

Dextromethorphan Added on for Children With Chronic Irritability

Start date: May 9, 2021
Phase: Phase 4
Study type: Interventional

Dextromethorphan Added on for Children With Chronic Irritability

NCT ID: NCT04776304 Completed - PTSD Clinical Trials

Art Therapy qEEG Study for Service Members With a Traumatic Brain Injury and Posttraumatic Stress Symptoms

ArtTherapy
Start date: October 30, 2021
Phase: N/A
Study type: Interventional

Service members and/or recently separated veterans with post traumatic stress symptoms and mild traumatic brain injury may participate in 8 sessions including 2 sessions including interviews and questionnaires as well as 6 sessions of art therapy. In the art therapy, participants will be provided with a blank paper mache mask template and invited to alter the mask however they wish using a variety of art materials. The therapist will use the art-making process and culminating product to aid in self-reflection, reframe negative thoughts and feelings, and work through traumatic content. Prior to the session start participants will get set up with a mobile qEEG (worn like a hat and backpack). The qEEG will measure brain activity in a non-invasive way throughout the art therapy session to improve understanding of brain activity during the art therapy process.