Irritable Bowel Syndrome (IBS) Clinical Trial
Official title:
Abdominal Symptom Phenotype: Pathways to New Biomarkers
Children and adults commonly suffer from recurrent abdominal (stomach) pain. One type is
called irritable bowel syndrome (IBS). IBS in adults and children is one of the most common
and costly health care problems in the US. Some children have pain frequently (recurrent
pain) while others rarely have pain. The investigators are conducting this study to help us
answer questions about the causes and treatments, and management of IBS in children.
The purpose of this study is to find out if there is more than one type of IBS in children.
If there is, this will be important in deciding the best treatments. The investigators also
want to learn how children with IBS differ from those who do not have recurrent abdominal
(stomach) pain.
Functional gastrointestinal (GI) disorders (FGIDs), in particular irritable bowel syndrome
(IBS) in adults and children, are among the most common and costly health care problems in
the US. IBS disproportionately affects adult women (10-15% in western nations) and
adolescent girls. Yet, health care providers remain challenged to provide effective clinical
management. The etiology of IBS is not well defined and likely multi-factorial.
A Need to Define Subgroups of IBS:
This study emerges from the claim that identification of patient subgroups will advance our
understanding of IBS and ultimately help develop treatment approaches. Most studies have
lumped together patients with IBS into 2 groups (constipation-, diarrhea-predominant) and
tested whether they differ from healthy controls. We propose that a paradigm shift is in
order. We should recognize that IBS likely has multiple causes and therefore, multiple
expressions. We speculate that by understanding better defined patient subgroups and linking
them to newer biomarkers or tests, ultimately will further the understanding of the origins
and create effective treatments.
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Observational Model: Case Control, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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||
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