Study of the Effects of Muscular Activity on Iron Metabolism

Status Recruiting

Clinical Trial Summary

The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will have to pedal on an ergocycle for 45 minutes, and urine and blood samples will be collected regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.

Clinical Trial Description

Hemojuvelin has been described as interfering with hepcidin, a key regulator of iron homeostasis. Hemojuvelin is mainly produced by muscle, and the relationship between exercise and iron metabolism can be questioned about.

The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will be investigated at two periods according to a cross-over design after:

1. 45 minutes of exercise on the ergocycle; and

2. no physical exercise.

Urine and blood samples will be collected at both periods regularly to measure hemojuvelin, hepcidin, iron and transferrin levels. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Open Label

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00378469
Study type	Interventional
Source	Rennes University Hospital
Contact	Pierre Brissot, MD
Phone	33-2-9928-4297
Email	pierre.brissot@univ-rennes1.fr
Status	Recruiting
Phase	N/A
Start date	September 2006

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01483768` - Study of Sleeve Gastrectomy on Iron Intestinal Absorption in Morbidly Obese Patients	N/A
Completed	`NCT02888171` - Impact of Ferric Citrate vs Ferrous Sulfate on Iron Parameters and Hemoglobin in Individuals With CKD and Iron Deficiency	N/A
Recruiting	`NCT02242188` - Supplementing Iron and Development in Breastfed Infants (SIDBI Study)	Phase 4
Completed	`NCT02714361` - A Study to Investigate the Effect of Vitamin D3 Supplementation on Iron Status in Iron Deficient Women	N/A
Completed	`NCT02176759` - Iron Absorption From Rice Fortified With Ferric Pyrophosphate	N/A
Completed	`NCT01991626` - Evaluation of the Effects of an Exogenous Phytase on Iron Absorption From LNS Added to Complementary Foods	N/A
Completed	`NCT01922479` - Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure	Phase 4
Completed	`NCT01687062` - Iron Absorption From Tef-injera in Women of Reproductive Age	N/A
Completed	`NCT01573013` - Iron Fortification Trail Using NaFeEDTA in Iron Deficient Lead-exposed Children	N/A
Completed	`NCT01191463` - The Efficacy of a Local Vitamin-C Rich Fruit (Guava) in Improving Iron Absorption From Mungbean Based Meals and Its Effect on Iron Status of Rural Indian Children (6-10 Years)	N/A
Completed	`NCT01443832` - Iron Absorption From Iron-fortified Fonio Porridge: a Stable Isotope Study	Phase 0
Completed	`NCT01061307` - An Efficacy Trial of Iron, Zinc and Vitamin A Fortified Rice in Children in Satun, Thailand	Phase 0
Not yet recruiting	`NCT00515918` - The Effect of Early Iron Deficiency on Developmental Brain and Behavior in Infants	N/A
Recruiting	`NCT05992116` - Iron Deficiency in Patients With Heart Failure and Reduced and Mildly Reduced Ejection Fraction
Completed	`NCT05262634` - Pregnancy Outcome in Women With an Iron Deficiency in the First Trimester
Completed	`NCT06080555` - Bioequivalence Study of Ferric Carboxymaltose Injection in Participants With Iron Deficiency Anaemia	Phase 1
Completed	`NCT04602247` - Evaluation of Iron Bioavailability From Iron Chlorophyllin	N/A
Completed	`NCT02996786` - Effects of Danggui Buxue Tang on Blood Biochemical Parameters in Male Recreational Runners	N/A
Completed	`NCT02175888` - The Optimization of Bioavailability From Iron Supplements: Study 1	N/A
Completed	`NCT02327299` - Iron Bioavailability From Cubes	N/A