Iron Deficiency Clinical Trial
Official title:
Study of the Effects of Muscular Activity on Iron Metabolism: A Pilot Study on Healthy Volunteers
The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will have to pedal on an ergocycle for 45 minutes, and urine and blood samples will be collected regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.
Hemojuvelin has been described as interfering with hepcidin, a key regulator of iron
homeostasis. Hemojuvelin is mainly produced by muscle, and the relationship between exercise
and iron metabolism can be questioned about.
The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in
healthy volunteers. Fourteen healthy male subjects will be investigated at two periods
according to a cross-over design after:
1. 45 minutes of exercise on the ergocycle; and
2. no physical exercise.
Urine and blood samples will be collected at both periods regularly to measure hemojuvelin,
hepcidin, iron and transferrin levels.
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Open Label
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